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Silkworm virus disease prevention and treatment silkworm drug and preparation method thereof

A virus disease, silkworm technology, applied in the direction of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of less research results, development space squeeze, etc., to control the progress of the disease course, have strong feasibility, Simple preparation process

Active Publication Date: 2014-12-31
平南县科学技术情报研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been researches on silkworm virus disease drugs, and some of the relevant research results can be applied to practice, such as: virus disease prevention and treatment of new drug virus treatment, through laboratory and rural production tests, it has been proved that it has a strong killing effect on silkworm virus disease pathogens Function, stable drug effect, obvious control effect, easy to control the concentration of use, non-toxic, no peculiar smell, non-corrosive, no adverse effects on silkworm physiology [Wang Gengxian et al. Research on the effect of virus treatment on silkworm virus disease control [J]. China Sericulture, 2004]; Silkworm Shaxing No. 1, new drug A, erythromycin and Canbingling compound have obvious inhibitory effects on nuclear polyhedrosis virus disease, and Silkworm Shaxing No. 1 has Significant effect [Shi Meining et al. Inhibition test of several drugs on silkworm pus disease [J]. Guangxi Sericulture, 2002]; silkworms can prevent and control silkworm virus after adding puweiling, liangcanling, compound phenol and other agents. It also plays an obvious role in the disease [Xi Changying et al. Preliminary report on silkworm Tianshi puuweiling, Liangcanling, and compound phenols test [J]. Sericulture Tea Communication, 2000], but as the choice of silkworm antiviral chemical drug components , because it is greatly restricted by its complex synthesis route and high price, it seems that the development space has been squeezed
However, the research on Chinese herbal medicines for silkworm virus disease is insufficient, and less research results can be applied to practice. For example, the patent application number 200610054277.8 "Silkworm medicine against viral silkworm disease" discloses an antiviral silkworm disease Silkworm medicine, including Chinese medicine Coptidis, Cortex Phellodendron, Astragalus, garlic, Banlangen, Angelica, Sangji, Epimedium, Ophiopogon japonicus, Earthworm, and Licorice, a total of 11 traditional Chinese medicines

Method used

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  • Silkworm virus disease prevention and treatment silkworm drug and preparation method thereof
  • Silkworm virus disease prevention and treatment silkworm drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Astragalus 1250g Dandelion 1250g Raisin 750g Atractylodes macrocephala 1000g

[0034] Honeysuckle 750g Licorice 1000g Gallnut 900g

[0035] Take all 7 raw materials and crush them to 10 meshes. After taking the materials according to the components, add 70L of 55% ethanol solution by volume fraction for the first time, reflux for 150min, and add 55L of 55% ethanol solution by volume fraction for the second time. , reflux extraction for 120min; combine the extracts, vacuum evaporate and concentrate 50L of the obtained extracts, and spray dry to obtain the active ingredient.

Embodiment 2

[0037] Astragalus 1000g, dandelion 750g, radish seed 400g, Atractylodes macrocephala 750g

[0038] Honeysuckle 600g Licorice 1000g Gallnut 500g

[0039]Take all 7 raw materials and crush them to 10 meshes. After taking materials according to the components, add 50L of 55% ethanol solution by volume fraction for the first time, reflux extraction for 150min, and add 40L of 55% ethanol solution by volume fraction for the second time. , reflux extraction for 120min; combine the extracts, evaporate and concentrate the obtained extracts in a vacuum to 35L and spray dry to obtain the active ingredient.

Embodiment 3

[0041] Astragalus 1500g Dandelion 1250g Raisin 1000g Atractylodes macrocephala 1250g

[0042] Honeysuckle 1250g Licorice 1500g Gallnut 1000g

[0043] Take all 7 raw materials and crush them to 10 meshes. After taking materials according to the components, add 85L of 55% ethanol solution by volume fraction for the first time, reflux extraction for 150min, and add 70L of 55% ethanol solution by volume fraction for the second time , reflux extraction for 120min; combine the extracts, vacuum evaporate and concentrate 60L of the obtained extracts, and spray dry to obtain the active ingredient.

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Abstract

The present invention discloses a silkworm virus disease prevention and treatment silkworm drug and a preparation method thereof. The silkworm drug mainly comprises the following raw materials: milkvetch root, dandelion, garden radish seed, largehead atractylodes rhizome, licorice root, honeysuckle, Chinese gall, Chinese honeylocust spine and the like. The preparation method mainly comprises the following steps: crushing raw herbs, carrying out reflux extraction, carrying out concentration, and drying. The silkworm drug has the following characteristics that: a treatment effect is significant, disease course progression can be effectively controlled, a significant prevention and treatment effect is provided for silkworm virus diseases, and characteristics of safety and no toxic-side effect are provided for humans and animals. In addition, the preparation method has characteristics of simple preparation process and strong feasibility, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a silkworm medicine for preventing and treating silkworm virus disease and a preparation method thereof. Background technique [0002] Silkworms are easily affected by pathogenic microorganisms, parasites or other external factors under the condition of intensive group rearing, which will affect the normal growth and development of silkworms and cause silkworm diseases, which endanger the yield and quality of silkworm cocoons. Once spread, it will also lead to The entire sericulture operation failed. In the middle of the 19th century, European sericulture suffered a devastating blow due to particulate disease. French L. Pasteur founded the female moth inspection method in 1999, which controlled the spread of the disease. Since then, Japan, China, etc. have also carried out scientific research on silkworm diseases. [0003] Silkworm virus disease is the most common and seriou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/484A61P31/12A61K35/64
Inventor 蒙建道
Owner 平南县科学技术情报研究所
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