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Application of Chukrasone B in preparing medicines for treating atherosclerosis

A technique for atherosclerosis and medicine, which is applied in the application field of Chukrasone B in the preparation of medicine for treating atherosclerosis, and can solve the problems that the etiology and pathogenesis have not been fully elucidated, and there are no preventive measures and therapeutic medicines.

Active Publication Date: 2013-10-23
JIANGSU SHENLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective preventive measures and therapeutic drugs.

Method used

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  • Application of Chukrasone B in preparing medicines for treating atherosclerosis
  • Application of Chukrasone B in preparing medicines for treating atherosclerosis
  • Application of Chukrasone B in preparing medicines for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Chukrasone B tablet involved in the present invention:

[0013] Take 20 grams of compound Chukrasone B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Chukrasone B capsules involved in the present invention:

[0015] Get 20 grams of compound Chukrasone B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] The present invention reveals the effect of Chukrasone B on atherosclerosis through cell level research and establishment of atherosclerosis model.

[0018] Oral and intravenous administration of Chukrasone B in the present invention can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Triesters, total cholesterol and low-density lipoprotein levels decreased, indicating that Chukrasone B can treat atherosclerosis.

[0019] Materials and Methods

[0020] 1. Experimental materials:

[0021] 1.1 Animals and fee...

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Abstract

The invention relates to an application of Chukrasone B in preparing medicines for treating atherosclerosis, wherein the Chukrasone B has the effect of preventing atherosclerosis by adjusting blood fat and protecting endothelial cells. Medicines prepared by Chukrasone B for treating atherosclerosis has a better curative effect to atherosclerosis, and can be used for treating atherosclerosis of human or animals. The use of the Chukrasone B in preparing medicines for treating atherosclerosis provided by the invention is disclosed for the first time. As the framework type belongs to a brand-new framework type, and the inhibiting activity of the Chukrasone B to atherosclerosis is unimaginably strong, the probability of giving any enlightenment by other compounds does not exist. The Chukrasone B has remarkable substantial characteristics and meanwhile has a remarkable progress for treating atherosclerosis.

Description

technical field [0001] The invention relates to the application of Chukrasone B in the preparation of medicines for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Chukrasone B involved in the present invention is published in 2012 (Liu, H. B. et al., 2012. Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis. Organic Letters 14 (17), 4438– 4441.), which has a new skeleton type, and its current use only involves potassium ion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P9/10
Inventor 丁圣雨
Owner JIANGSU SHENLONG PHARMA
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