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Methods and systems for assessing vascular endothelial function

A vascular endothelial and functional technology, applied in catheters, cardiac catheters, blood flow measurement, etc., can solve problems such as limited use, expensive, and inapplicable

Active Publication Date: 2015-10-14
UNIV JAGIELLO SKI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is quite expensive, requires sophisticated equipment and a highly specialized operator, is highly operator-dependent and has poor reproducibility due to measurement variability and poor resolution relative to arterial size
Therefore, its use is limited and the method is not applicable on a more routine basis

Method used

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  • Methods and systems for assessing vascular endothelial function
  • Methods and systems for assessing vascular endothelial function
  • Methods and systems for assessing vascular endothelial function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] NADH fluorescence of skin cells from the hands of human subjects and changes in the intensity of this fluorescence following occlusion of the brachial artery and release of blood flow were measured. The health status of the subjects was not checked.

[0094] Measurements were performed using a Carry Eclipse fluorescence spectrophotometer equipped with a xenon flash lamp, a fiber optic system with a probe suitable for measuring emissions from solid surfaces, and a PMT detector.

[0095] The excitation light has a wavelength of 350 nm and the monitored emission signal has a wavelength of 460 nm.

[0096] Fluorescence signal intensity from the back of the subject's palm between the thumb and index finger ("indicator" finger) was recorded for 2 minutes (first time period), during which time a steady state corresponding to the initial baseline was reached.

[0097] Two minutes later, the brachial artery in the same hand was occluded by inflating and tightening the inflatabl...

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Abstract

A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.

Description

technical field [0001] The present invention relates to a non-invasive method of assessing vascular endothelial function and a system for performing said method. Background of the invention [0002] Vascular endothelium is the layer of cells that lines the inside of blood vessels, including arteries and veins. The endothelium is currently recognized as an important metabolically active autocrine / paracrine / endocrine organ that regulates cardiovascular function and maintains vascular homeostasis by: regulating vascular tone; modulating solute transport into the cells of the vessel wall components, local cell growth, and deposition of extracellular matrix; protect blood vessels from potentially deleterious effects of circulating substances and cells within blood vessels; and modulate hemostatic, inflammatory, and repair responses to local injury. A major function of the endothelium is to produce or release substances, such as nitric oxide (NO), which control the behavior of bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/02A61B5/026A61B5/1455A61B5/024A61B5/145
CPCA61B5/0071A61B5/02007A61B5/02422A61B5/0261A61B5/14546A61B5/14556
Inventor 耶日·杰比奇安杰伊·马尔茨奈克斯蒂芬·基奥皮奇
Owner UNIV JAGIELLO SKI
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