Rabbit portal vein thrombosis model

A technology for portal vein thrombosis and venous thrombosis, which is applied in the field of model preparation, and can solve problems such as complex production methods, long taking time, and difficult management after modeling

Inactive Publication Date: 2014-03-19
HUZHOU CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] CN101961465A (2011-2-2) discloses a traditional Chinese medicine for treating portal vein thrombosis, but the traditional Chinese medicine needs to be taken for a long time and has little effect on preventing portal vein thrombosis
According to comprehensive literature reports, t

Method used

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  • Rabbit portal vein thrombosis model
  • Rabbit portal vein thrombosis model
  • Rabbit portal vein thrombosis model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] A piercing device, such as Figures 3 to 5 As shown, including the puncture needle 1, the puncture needle 1 is sleeved with a hose 2, there is a slight gap between the puncture needle 1 and the hose 2, the hose 2 is sleeved with a support tube 3, and the head end of the hose 2 is connected to the support tube 3 head ends are attached to each other, and the tail end of support pipe 3 exceeds the tail end of hose 2 .

[0073] A flange 31 is provided at the junction of the support tube 3 and the end of the hose 2; the puncture needle 1 includes a needle head 11, and a needle cap 111 is provided at the tail of the needle head 11, and the needle cap 111 is threadedly connected to a handle 12, and the end of the handle 12 close to the support tube 3 is A limit edge 121, a spring 4 is arranged between the flange 31 and the limit edge 121. When the support tube 3 is ejected, the head end of the support tube 3 and the flexible pipe 2 should only slightly exceed the needle point ...

Embodiment 2

[0083] Embodiment 2: The difference with Embodiment 1 is that, as Figure 6 As shown, the hose 2 is a straight pipe, and a plurality of slots 23 are opened on the side of the head of the straight pipe.

[0084]

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Abstract

The invention relates to model preparation, particularly to a rabbit portal vein thrombosis model which establishes a rabbit portal vein thrombosis model by a portal vein ligation catheterization method. The experimental animal adopts a New Zealand white rabbit; the experimental process comprises the steps of preoperative preparation: a preoperative experimental rabbit fasts all night and freely drinks water; anaesthetization; operation method: make the preoperative preparations including shaving feathers at the operating area after anaesthetization, disinfection and the like, enter the belly layer by layer, separate a portal vein, insert a 2Fr internal jugular vein tube by a catheterization method, ligate the portal vein using the tube as the inner support, suture and fix, lead to outside of body, and then conducting firm fixing. The model of the invention causes partial blood stasis, annular oppressed damage of blood vessel endothelium by ligating the portal vein, simultaneously carries out tube stimulation, starts intrinsic and extrinsic coagulation processes, increases the incidence of thromboembolism, and provides passages for the later partially collecting blood specimen, dynamic venogram, partial injection and the like; the first PVT occurrence time is about 30 min after the model is found via the portal vein radiography, and the model formation rate is higher than 75%.

Description

technical field [0001] The invention relates to model preparation, in particular to a rabbit portal vein thrombosis model. Background technique [0002] Portal vein thrombosis (portal vein thrombosis, PVT) refers to the thrombus that occurs in the main portal vein, superior mesenteric vein, inferior mesenteric vein or splenic vein. It is one of the serious complications after splenectomy (or combined vascular devascularization)[1]. Okuda reported the autopsy results of 247,728 patients from the Japanese Pathological Association, the incidence of portal vein thrombosis was 0.55%, the incidence of portal vein thrombosis in patients with liver cirrhosis was 6.59%, and the incidence of PVT after splenectomy was 37.5% to 43.5% [2]. Once PVT forms, it can lead to hepatic hypoperfusion and aggravated gastrointestinal congestion, and acute mesenteric venous thrombosis can lead to intestinal necrosis; extensive portal thrombosis will seriously affect the success rate of later liver ...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61D7/00A61K49/00
Inventor 魏云海张国雷戴利成慎华平吴万波徐杰伟
Owner HUZHOU CENT HOSPITAL
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