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Drug for treating senile dementia

A technology for Alzheimer's disease and medicine, which is applied in the field of medicine for the treatment of Alzheimer's disease. It can solve the problems of limited improvement of Alzheimer's disease symptoms, inability to cure Alzheimer's disease, and side effects of the nervous system, so as to prevent neuron damage and slow down cognitive impairment. Cognitive dysfunction, slow down the effect of memory function decline

Inactive Publication Date: 2014-08-20
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs currently on the market are mainly drugs that increase cholinergic function, such as cholinesterase inhibitors galantamine, donepezil (Aricept), M receptor agonist Zanomelin, etc. These drugs can only delay the onset process , but does not cure Alzheimer's disease and is associated with cardiovascular and gastrointestinal side effects
Other commonly used drugs such as antidepressants, anxiolytics, sedative hypnotics, antipsychotics and other drugs have limited improvement in the symptoms of Alzheimer's disease, and have neurological side effects

Method used

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  • Drug for treating senile dementia
  • Drug for treating senile dementia
  • Drug for treating senile dementia

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Experimental program
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Embodiment Construction

[0014] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0015] A medicament for treating senile dementia, the active ingredient of the medicament is brilliant blue G, and the molecular formula of the brilliant blue G is C 47 h 48 N 3 NaO 7 S 2 , the molecular weight is 854.02, and its structural formula is .

[0016] The aforementioned brilliant blue G is a pharmacologically acceptable salt or solvate.

[0017] The above-mentioned agents are used as drugs for alleviating memory function impairment and cognitive function impairment in senile dementia.

[0018] The above-mentioned agents are used as drugs having a neuroprotective effect on senile dementia.

[0019] 1. Experimental animals:

[0020] Male ICR mice weighing 25 to 30 g were used in the experiment. Divided into 4 groups, normal control group, β-amyloid (Aβ) group, BBG administration group, Aβ and BBG administration group, 8 rats...

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Abstract

The invention relates to a drug for treating senile dementia. The effective component of the drug is brilliant blue G, the molecular formula of the brilliant blue G is 47H48N3NaO7S2, the molecular weight is 854.02, the structural formula of the brilliant blue G is as shown in the specification; the drug can be used for effectively alleviating the symptoms of senile dementia, relieving memory dysfunction of senile dementia, relieving cognitive disorder of senile dementia and preventing neuron damage caused by senile dementia, and the drug has high efficiency and safety for treating the senile dementia.

Description

technical field [0001] The invention relates to the field of treating senile dementia, in particular to a medicament for treating senile dementia. Background technique [0002] The pathogenesis of senile dementia (also known as Alzheimer's disease) is still unclear. Drugs currently on the market are mainly drugs that increase cholinergic function, such as cholinesterase inhibitors galantamine, donepezil (Aricept), M receptor agonist Zanomelin, etc. These drugs can only delay the onset process , but it cannot cure Alzheimer's disease, and it is accompanied by cardiovascular and gastrointestinal side effects. Other commonly used drugs such as antidepressants, anti-anxiety, sedative-hypnotics, antipsychotics and other drugs have limited improvement in the symptoms of Alzheimer's disease, and have neurological side effects. In view of this, there is a need for a more efficient and safe agent for treating Alzheimer's disease. [0003] In recent decades, the hypothesis that the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/255A61P25/28
Inventor 陈晓薇王钦文王闯徐淑君张俊芳魏晓菲
Owner NINGBO UNIV
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