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Dibutylhydroxytoluene-containing preparation, and method for stabilizing dibutylhydroxytoluene

A technology of dibutyl hydroxytoluene and polybutylene terephthalate, which is applied in the direction of medical preparations of non-active ingredients, nebulizers for treatment, anti-toxic agents, etc., can solve the problem of improving dibutyl hydroxytoluene Problems such as the stability of butylated hydroxytoluene over time and the decrease in the content of dibutyl hydroxytoluene are not fully understood, and the effect of maintaining the antioxidant effect and inhibiting the decrease in content is achieved

Active Publication Date: 2014-08-27
SENJU PHARMA CO LTD
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Problems solved by technology

[0005] Although there are numerous reports on preparation technology using dibutyl hydroxytoluene, the current situation is that the main reason for the decrease in the content

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  • Dibutylhydroxytoluene-containing preparation, and method for stabilizing dibutylhydroxytoluene
  • Dibutylhydroxytoluene-containing preparation, and method for stabilizing dibutylhydroxytoluene
  • Dibutylhydroxytoluene-containing preparation, and method for stabilizing dibutylhydroxytoluene

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Abstract

The purpose of the present invention is to provide a technique for preventing the decrease in the content of dibutylhydroxytoluene in a preparation and improving the stability of dibutylhydroxytoluene. In a container in which a dibutylhydroxytoluene-containing preparation is to be contained, a resin containing at least one polymer selected from the group consisting of polybutylene terephthalate, polyethylene terephthalate, polystyrene, acrylonitrile butadiene styrene, polycarbonate, polymethyl methacrylate and an ethylene-(vinyl alcohol) copolymer is used as a resin constituting the inner wall surface (a wall surface of an interior space in an expulsion section and/or a wall surface of a lid which faces an expulsion outlet of the expulsion section) of the container. It becomes possible to prevent the adsorption of dibutylhydroxytoluene onto the expulsion section and keep the content of dibutylhydroxytoluene in the preparation steadily.

Description

technical field [0001] The present invention relates to a preparation capable of stably maintaining dibutyl hydroxytoluene. Furthermore, the present invention relates to a method for stabilizing dibutylhydroxytoluene. Background technique [0002] In recent years, preparations with various effects have been developed in the fields of medicine, food, and cosmetics. In these formulations, in order to prevent the oxidation of the components contained, it is required to incorporate an antioxidant. [0003] Currently, dibutylhydroxytoluene (BHT) is known as a representative compound of fat-soluble antioxidant. As fat-soluble antioxidants, tocopherol and butyl hydroxyanisole are also known, but dibutyl hydroxytoluene has a stronger antioxidant effect than other fat-soluble antioxidants, and it is widely used in medicine, food, and cosmetics. Products and other fields are widely used. So far, there have been many reports on formulation techniques using dibutylhydroxytoluene. F...

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Application Information

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IPC IPC(8): A61K47/10A61J1/05A61K9/08A61K47/34
CPCA61J1/067A61M2210/0618A61M11/008A61F9/0008A61M2210/0612A61M15/08A61P27/02A61P29/00A61P39/06
Inventor 根本夫规子大塚忠史
Owner SENJU PHARMA CO LTD
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