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pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same

A sensitive and carrier-based technology, applied in the direction of medical preparations containing active ingredients, carrier-bound/immobilized peptides, chemical instruments and methods, etc., can solve problems with sensitivity and insufficient functions

Active Publication Date: 2017-08-22
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Many pH-sensitive liposomes and some biodegradable materials have the following problems: they are sensitive under relatively low pH conditions and have only insufficient functions

Method used

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  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same
  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same
  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same

Examples

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Embodiment

[0158] Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these Examples at all.

[0159]

[0160] In the examples, the following compounds were used. If the reagent name is the same as the product name, the product name is omitted.

[0161] ・EYPC (non-hydrogenated egg yolk phosphatidylcholine: manufactured by NOF, COATSOME NC-50)

[0162] ・HSPC (soybean phosphatidylcholine: manufactured by NOF Corporation, COATSOME NC-21)

[0163] DDPC (1,2-Didecanoyl-sn-glyceryl-3-phosphatidylcholine: COATSOME MC-1010 manufactured by NOF Corporation)

[0164] DLPC (1,2-dilauroyl-sn-glyceroyl-3-phosphatidylcholine: COATSOME MC-1212 manufactured by NOF Corporation)

[0165] ・DMPC (1,2-Dimyristoyl-sn-glyceryl-3-phosphatidylcholine: manufactured by NOF Corporation, COATSOMEMC-4040)

[0166] ・DPPC (1,2-dipalmitoyl-sn-glyceryl-3-phosphatidylcholine: manufactured by NOF Corporation, COATSOME MC-6060)

[0167] DSPC (1,...

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Abstract

[Object] To provide a pH sensitive carrier which can serve as a carrier for physiologically active substance and is able to develop a membrane disruptive function promoting effect in response to a weakly acidic environment and its preparation method, and also to provide a pH sensitive drug and a pH sensitive drug composition each containing the carrier, and a culture method using the same. [Solution] A pH sensitive carrier which includes at least one pH sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and ±-tocopherol, and which is capable of developing a membrane disruptive function promoting effect.

Description

technical field [0001] The present invention relates to a pH-sensitive carrier, a method for producing the carrier, a pH-sensitive drug containing the carrier, a pH-sensitive drug composition, and a culture method using the carrier. More specifically, the present invention relates to a pH-sensitive carrier that is useful as a DDS (Drug Delivery System) and exhibits a membrane-disrupting function-promoting effect in response to a weakly acidic environment, a method for producing the same, and a pH-sensitive carrier containing the carrier. Sensitive drug, pH-sensitive drug composition and culture method using same. Background technique [0002] In recent years, studies on DDS mediators (carriers) for delivering physiologically active substances to necessary sites in necessary amounts have been vigorous. Stimuli-responsive mediators have attracted attention from the viewpoint of improvement in accumulation and selection of delivery sites, and many studies have been reported th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/28A61K9/107A61K9/127A61K38/00A61K47/14A61K47/22A61K47/24C07K17/02
CPCA61K9/1075A61K9/1272A61K38/00A61K38/02A61K47/28A61K9/107A61K9/127A61K47/14A61K47/22A61K47/24A61K47/10
Inventor 坂口奈央树
Owner TERUMO KK
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