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pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same

A sensitive and carrier-based technology, applied in the direction of medical preparations containing active ingredients, carrier-bound/immobilized peptides, chemical instruments and methods, etc., can solve problems with sensitivity and insufficient functions

Active Publication Date: 2017-08-22
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Many pH-sensitive liposomes and some biodegradable materials have the following problems: they are sensitive under relatively low pH conditions and have only insufficient functions

Method used

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  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same
  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same
  • pH-sensitive carrier and production method thereof, pH-sensitive drug containing the same, pH-sensitive drug composition, and culture method using the same

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Embodiment

[0158] Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these Examples at all.

[0159]

[0160] In the examples, the following compounds were used. If the reagent name is the same as the product name, the product name is omitted.

[0161] ・EYPC (non-hydrogenated egg yolk phosphatidylcholine: manufactured by NOF, COATSOME NC-50)

[0162] ・HSPC (soybean phosphatidylcholine: manufactured by NOF Corporation, COATSOME NC-21)

[0163] DDPC (1,2-Didecanoyl-sn-glyceryl-3-phosphatidylcholine: COATSOME MC-1010 manufactured by NOF Corporation)

[0164] DLPC (1,2-dilauroyl-sn-glyceroyl-3-phosphatidylcholine: COATSOME MC-1212 manufactured by NOF Corporation)

[0165] ・DMPC (1,2-Dimyristoyl-sn-glyceryl-3-phosphatidylcholine: manufactured by NOF Corporation, COATSOMEMC-4040)

[0166] ・DPPC (1,2-dipalmitoyl-sn-glyceryl-3-phosphatidylcholine: manufactured by NOF Corporation, COATSOME MC-6060)

[0167] DSPC (1,...

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Abstract

The present invention provides a pH-sensitive carrier that can serve as a carrier for physiologically active substances and exhibit a membrane-destroying function-promoting effect in response to a weakly acidic environment, a manufacturing method thereof, and a pH-sensitive drug and a pH-sensitive drug combination containing the carrier. Objects, and cultivation methods using the same. The pH-sensitive carrier exhibits a membrane destruction function promoting effect and includes: selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, higher bile acids, glycinodeoxycholic acid, and licorice. At least one pH-sensitive compound among acid, glycyrrhetinic acid and their salts; and phosphatidylcholine with 10 to 12 carbon atoms and polyoxyethylene sorbitan monofat with 12 to 18 carbon atoms. Acid esters, sorbitan fatty acid esters with 16 to 18 carbon atoms, glyceryl monooleate, glyceryl dilaurate, glyceryl distearate, glyceryl dioleate, polyoxyethylene castor oil and At least one amphiphilic substance in α-tocopherol.

Description

technical field [0001] The present invention relates to a pH-sensitive carrier, a method for producing the carrier, a pH-sensitive drug containing the carrier, a pH-sensitive drug composition, and a culture method using the carrier. More specifically, the present invention relates to a pH-sensitive carrier that is useful as a DDS (Drug Delivery System) and exhibits a membrane-disrupting function-promoting effect in response to a weakly acidic environment, a method for producing the same, and a pH-sensitive carrier containing the carrier. Sensitive drug, pH-sensitive drug composition and culture method using same. Background technique [0002] In recent years, studies on DDS mediators (carriers) for delivering physiologically active substances to necessary sites in necessary amounts have been vigorous. Stimuli-responsive mediators have attracted attention from the viewpoint of improvement in accumulation and selection of delivery sites, and many studies have been reported th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/28A61K9/107A61K9/127A61K38/00A61K47/14A61K47/22A61K47/24C07K17/02
CPCA61K9/1075A61K9/1272A61K38/00A61K38/02A61K47/28A61K9/107A61K9/127A61K47/14A61K47/22A61K47/24A61K47/10
Inventor 坂口奈央树
Owner TERUMO KK
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