New use of organic-inorganic hybrid polyanion oxometallate compounds

Abstract

The invention discloses a new use of organic-inorganic hybrid polyanion oxometallate compounds with the formulas of Na3[AlMo6(OH)6O18]}(H2D-Thr)2 and Na3[AlMo6(OH)6O18]}(H2D-Arg)2. The new use is an application of the organic-inorganic hybrid polyanion oxometallate compounds with the formulas of Na3[AlMo6(OH)6O18]}(H2D-Thr)2 and Na3[AlMo6(OH)6O18]}(H2D-Arg)2 in the preparation of anti-snake-venom drugs. Experiment results show that amino acid modified Anderson type polyanions can neutralize snake venom and can further reduce snake venom and bite wound aches (twitch, injured part licking and other discomfort symptoms) of mice, so the invention provides a new idea for development of anti-snake venom preparations, and has great scientific significance and wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the new application of organic-inorganic hybrid polyanoxometalate compounds. Background technique [0002] Snake venom is a liquid secreted by poisonous snakes from the venom glands. The main component is toxic protein, which accounts for about 90% to 95% of the dry weight. There are more than 20 kinds of enzymes and toxins. In addition, it also contains some small molecular peptides, amino acids, carbohydrates, lipids, nucleosides, biogenic amines and metal ions. The composition of snake venom is very complex, and the toxicity, pharmacology and toxicological effects of different snake venoms have their own characteristics. [0003] Venomous snake bites have the characteristics of acute onset, rapid changes, many complications, complicated treatment, disability, and high fatality rate. If the treatment is not timely or inappropriate, it often leads to adverse cons...

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Problems solved by technology

[0004] A venomous snake bite can seriously aggravate the injury and lead to a greatly increased mortality rate if left untreated

Although antivenom can effectively neutralize the corresponding snake venom, there are many problems in practical application: first, the specificity of the venom is strong, the snake species must be identified before medication, and the best curative effect can be achieved by medication immediately after the bite. Because it is expensive and difficult to store for a long time, it is not easy to get available antivenom in time even in developed areas, and it is even more difficult in mountainous areas with inconvenient transportation; in addition, antivenom is prone to allergies, some clinicians emphasize Do not use antivenom as a routine drug for snakebite, but only use it when there are obvious symptoms of systemic poisoning

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