Pharmaceutical fluidized bed particle diameter distribution online detection device based on differential pressure sampling

A pharmaceutical fluidized bed and detection device technology, applied in the direction of measurement device, particle and sedimentation analysis, particle size analysis, etc., to reduce the introduction of human error and pollution, improve the detection environment, reduce the detection speed and additional cleaning accessories. Effect

Inactive Publication Date: 2015-12-16
ZHEJIANG UNIV
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Problems solved by technology

[0005] In order to solve the problem of how to use low-cost equipment to accurately detect the diameter distribution of solid particles in a fluidized bed on-line, the present invention provides an on-line detection device for particle diameter distribution in a granulation fluidized bed

Method used

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  • Pharmaceutical fluidized bed particle diameter distribution online detection device based on differential pressure sampling
  • Pharmaceutical fluidized bed particle diameter distribution online detection device based on differential pressure sampling
  • Pharmaceutical fluidized bed particle diameter distribution online detection device based on differential pressure sampling

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Embodiment Construction

[0046] Such as figure 1 As shown, the on-line detection device for the diameter distribution of pharmaceutical fluidized bed particles based on differential pressure sampling is installed outside the fluidized bed reaction chamber.

[0047] Such as figure 2 and image 3 As shown, the detection device has a sampling mechanism I, a recovery mechanism II and a detection mechanism III; the inner cavities of the sampling mechanism I, the recovery mechanism II and the detection mechanism III are connected to each other to form a sealed space isolated from the outside world; the sampling mechanism I has a sampling sleeve 2. Sampling piston 3 and sampling pusher 4; a sampling channel is opened on the fluidized bed reaction chamber, and the sampling channel communicates with the inner cavity of the sampling sleeve 2; the sampling piston 3 is composed of a piston rod 31 and a plug 32 (such as Figure 5 As shown), the piston rod 31 is tightly matched with the sampling sleeve 2, the pi...

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Abstract

A pharmaceutical fluidized bed particle diameter distribution online detection device based on differential pressure sampling is installed outside a fluidized bed reaction chamber. The detection device is provided with a sampling mechanism, a recycling mechanism and a detection mechanism. The sampling mechanism is provided with a sampling sleeve, a sampling piston and a sampling pushing piece. The fluidized bed reaction chamber is provided with a sampling channel communicated with an inner cavity of the sampling sleeve. The sampling piston is composed of a piston rod and a plug, the piston rod is in sealing fit with the sampling sleeve and is connected with the sampling pushing piece, and the plug penetrates through the sampling channel to be located in the fluidized bed reaction chamber. When the sampling pushing piece is located at a first limit position, the plug closes the sampling channel; when the sampling pushing piece is located at a second limit position, the plug opens the sampling channel. The sampling mechanism inputs samples into the detection mechanism through a deceleration guide tube. The detection device has the advantages that real-time particle diameter detection is led out of the fluidized bed reaction chamber, so that the detection environment is improved, and the requirements for the detection speed and additional accessory cleaning of detection equipment are lowered.

Description

technical field [0001] The invention relates to a detection device capable of on-line detection of particle diameter distribution in a granulation fluidized bed. technical background [0002] The granulation fluidized bed completes granulation, coating and drying in one step in the pharmaceutical process, and is widely used in the pharmaceutical production process. [0003] The particle diameter range produced by the fluidized bed not only affects the next step of the process, but also affects the quality of the final drug. The operating parameters of the existing granulation fluidized bed are fixed during production, and the batches and environment of raw materials will change with time, and the operating parameters cannot be changed with these changes, which will result in poor quality consistency of the obtained drugs , even fails. Real-time online detection of particle diameter can change the operating parameters according to these changes, so that the particle diamete...

Claims

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Application Information

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IPC IPC(8): G01N15/02
Inventor 魏燕定田埂方升陈立赵洁金立帅储燎原瞿海斌
Owner ZHEJIANG UNIV
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