3results about How to "Reduce testing requirements" patented technology

The application provides a method for improving the sensitivity of liquid chromatography-mass spectrometry in detecting vitamin K1 in serum, which comprises the following steps: preparing a sample solution of vitamin K1 to be detected by using a liquid-liquid extraction method to obtain an initial sample solution; and redissolving the initial sample solution by using an aqueous solution containing at least isopropanol as a redissolving agent to obtain a sample solution to be detected; and adding ammonium fluoride after an LC-MS column to improve the mass spectrometry detection sensitivity of the vitamin K1 sample. By using the technical scheme of the application, isopropanol or isopropanol+methanol is used as a redissolving agent to replace methanol in the prior art as a redissolving agent, the mass spectrometry detection sensitivity of VK1 is improved, the recovery rate is improved, the detection method has good stability, and the clinical detection requirements can be met; meanwhile, the ammonium fluoride in the liquid chromatography can be completely replaced, the system pressure of the liquid chromatograph is reduced, and the service life of the chromatographic column is prolonged.

The invention discloses an on-line monitoring device and method for a double-screw continuous granulation process fusing near infrared-Raman-vision multi-mode data. The device comprises a device main body which is arranged at an outlet of a double-screw granulator and is used for receiving sample particles in a falling process; the near infrared spectrum detection mechanism is arranged on one side of the device main body and is used for detecting the moisture content in the sample particles; the Raman spectrum detection mechanism is arranged on the other side of the device main body and is used for detecting active pharmaceutical ingredients in the sample particles; and the visual detection mechanism is arranged in front of the device main body and is used for carrying out image acquisition and processing on the sample particles in the falling process. The detection units are mutually independent, do not interfere with each other, do not damage samples, are used for solving the technical problem that multi-modal data fusion and analysis of different process analysis sensors are difficult to meet in the online monitoring process of twin-screw continuous granulation, and accurate and reliable online detection of key quality attributes of particles in the twin-screw granulation process is realized.

This utility model discloses a pressure resistance testing device for liquid crystal displays. A support beam is installed at the lower part of a frame-like testing frame, and vacuum suction cups are mounted on the support beam. A carrier plate is installed on the testing frame above the support beam. Each carrier plate has a lower pressure sensor, and through holes are provided on the carrier plate corresponding to each vacuum suction cup. Pressure driving components are installed at the top of the testing frame via the support plate, with the lower end of each pressure driving component extending through the support plate to its lower end. An upper pressure sensor is installed at the lower end of each pressure driving component. The lower pressure sensors, upper pressure sensors, and pressure driving components are electrically connected to a control device. This utility model can quickly clamp and fix liquid crystal displays for pressure resistance testing, and requires less operator skill. It effectively replaces manual operation, reduces labor intensity, and solves the problem of inaccurate test results due to uncontrollable manual testing force and frequency, significantly improving testing accuracy and efficiency.