Particle diameter distribution online detecting device of granulating fluidized bed

Abstract

Provided is a particle diameter distribution online detecting device of a granulating fluidized bed. The detecting device is installed outside a reaction chamber of the fluidized bed and comprises a sealed shell. A sampling mechanism capable of extending into the reaction chamber of the fluidized bed to take out samples is arranged in the shell. The sampling mechanism is located at the sampling station when extending into the reaction chamber of the fluidized bed and located at the dispersion station when getting out of the reaction chamber of the fluidized bed to make the samples fall. The sampling mechanism reciprocates between the sampling station and the dispersion station and is in seal fit with the chamber wall of the reaction chamber of the fluidized bed. A visual detecting mechanism is arranged in the shell, and comprises a light source and a camera for shooting the sample falling process. A recovery mechanism for collecting the samples is arranged in the shell. The particle diameter distribution online detecting device has the advantages that real-time detection of particle diameter is completed outside the reaction chamber of the fluidized bed, the detection environment is improved, the detection speed of the detection device is increased, and the requirement for additionally cleaning accessories is lowered.

Description

technical field [0001] The invention relates to a detection device capable of on-line detection of particle diameter distribution in a granulation fluidized bed. technical background [0002] The granulation fluidized bed completes granulation, coating and drying in one step in the pharmaceutical process, and is widely used in the pharmaceutical production process. [0003] The particle diameter range produced by the fluidized bed not only affects the next step of the process, but also affects the quality of the final drug. The operating parameters of the existing granulation fluidized bed are fixed during production, and the batches and environment of raw materials will change with time, and the operating parameters cannot be changed with these changes, which will result in poor quality consistency of the obtained drugs , even fails. Real-time online detection of particle diameter can change the operating parameters according to these changes, so that the particle diamete...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of how to use low-cost equipment to accurately detect the diameter distribution of solid particles in a fluidized bed on-line, the present invention provides an on-line detection device for particle diameter distribution in a granulation fluidized bed

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