Method for detection and quantification of Chinese medicine smell and corresponding disease by using electronic nose and electronic tongue sensor technology

A technology of sensor technology and quantification method, which is applied in the field of traditional Chinese medicine detection, and can solve the problems of quantification and inseparability without modern instruments.

Inactive Publication Date: 2015-12-23
盛良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The four qi and five flavors are the core of the medicinal properties of traditional Chinese medicine, but so far there is no modern instrument for detection and quantification
If the above complex situations can only detect and quantify odors but cannot be classified according t

Method used

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  • Method for detection and quantification of Chinese medicine smell and corresponding disease by using electronic nose and electronic tongue sensor technology
  • Method for detection and quantification of Chinese medicine smell and corresponding disease by using electronic nose and electronic tongue sensor technology
  • Method for detection and quantification of Chinese medicine smell and corresponding disease by using electronic nose and electronic tongue sensor technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1. Electronic tongue detection and quantification of Qinghua heat phlegm medicine

[0046] 1. Purpose The electronic tongue can detect and quantify the smell of traditional Chinese medicine and its corresponding syndrome

[0047] 2. Materials and methods

[0048] 2.1. Detection instrument: Smartongue, purchased by Shanghai Ruifeng International Trade Co., Ltd.

[0049] 2.2. Testing conditions: Working temperature: 10-30°C Working humidity: 0-80%

[0050] 2.3. Sample preparation: Drug dosage: Weigh the drugs according to the dosage in Table 1, add 5ml of distilled water each, soak for 30 minutes, heat with a heater at 80°C for 30 minutes, cool and put them in a constant temperature device at 37°C to keep warm and test.

[0051] 2.4. Test drugs All test drugs are standard products purchased by China Pharmaceutical and Biological Products Inspection Institute. Each sample was tested 3 times. The identified traditional Chinese medicines were crushed through 80-m...

Embodiment 2

[0068] Example 2. Quantification of detection and quantification of electronic tongue with the same smell and similar smell of Qinghua heat phlegm medicine

[0069] 1. Objective The electronic tongue can detect and quantify the same and similar smell of traditional Chinese medicine, but it cannot correspond to the syndrome. Therefore, the verification, detection and quantification of the smell of traditional Chinese medicine must be carried out at the same time as its corresponding syndrome.

[0070] 2. Materials and methods

[0071] 2.1. Testing instruments, testing conditions, and sample preparation are the same as Example 1.

[0072] 2.2. Detecting medicines: Table 3 is the same as Example 1, and the following smells are the same and similar but different medicines corresponding to syndrome efficacy:

[0073] table 3

[0074] drug name

the smell

Dosage (g)

Efficacy (Odor Correspondence Certificate)

[0075] Jiaogulan

bitterness, c...

Embodiment 3

[0087] Example 3. Detection and Quantification of Electronic Tongue of Chinese and Western Medicines for Clearing Heat and Cooling Blood

[0088] 1. Purpose The electronic tongue can detect and quantify the smell of western medicine and Chinese medicine and its corresponding syndrome.

[0089] 2. Materials and methods

[0090] 2.1. Testing instruments, testing conditions and sample preparation are the same as Example 1.

[0091] 2.2. Tested drugs: Rehmannia glutinosa (sdh) 0.1, sweet, cold; Scrophulariaceae (xs) 0.1, sweet, bitter, salty, slightly cold; Radix Paeoniae Alba (ds) 0.1, bitter, slightly cold; Cortex Moutan (mdp) 0.1, bitter and pungent , slightly cold; western medicine 3.6.1 cefotaxime sodium 0.1, 3.7.1 ceftazidime 0.1

[0092] 3. Results

[0093] Using PCA and DFA to detect and quantify the above drugs with electronic tongue, the results are as follows:

[0094] 3.1. Figure 7 PCA plot for clearing heat and cooling blood medicine

[0095] 3.2. Figure 8 DFA ...

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Abstract

The invention is a method for detection and quantification of Chinese medicine smell and corresponding disease by using electronic nose and electronic tongue sensor technology. The method is not only suitable for traditional Chinese medicine but also for detection and quantification of Western medicines converted to traditional Chinese medicines; and the detection and quantification of medicine smell and corresponding disease for food and health care products are contained in the invention. The method includes the following steps: 1) establishing a unified standard detection and quantification fingerprint database for traditional Chinese medicine smell and corresponding disease; 2) acquiring a detection and quantification fingerprint of the smell and the corresponding disease of a traditional Chinese medicine to be tested; 3) comparing the detection and quantification fingerprint of the smell and the corresponding disease of a traditional Chinese medicine to be tested with the unified standard detection and quantification fingerprint for traditional Chinese medicine smell and corresponding disease and determining the smell and the corresponding disease of the traditional Chinese medicine to be tested.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine detection, and in particular relates to a method for detecting and quantifying the smell of traditional Chinese medicine and its corresponding syndrome by using electronic nose and electronic tongue sensor technology. Background technique [0002] The five elements are the theoretical basis of traditional Chinese medicine, so the smell of traditional Chinese medicine refers to the four airs: cold, cool, warm, and hot (flat), and the five flavors: sour (astringent), bitter, sweet (light), pungent, and salty. The four qi and five flavors are the core of the medicinal properties of traditional Chinese medicine, but so far there is no modern instrument to detect and quantify them. The most obvious is that there is no invention to detect and quantify the four gases. The detection of the five flavors is based on the invention of the Western five tastes: sour, bitter, sweet, salty, and fresh....

Claims

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Application Information

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IPC IPC(8): G01N33/15
Inventor 盛良陈建伟张亚刘学华
Owner 盛良
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