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Application of AMO-134 in preparation of medicine for treating arrhythmia

A 1. AMO-134, arrhythmia technology, applied in gene therapy, drug combination, pharmaceutical formula, etc., can solve the problems of hERG transport disorder and so on

Inactive Publication Date: 2016-01-27
NINGBO MEDICAL CENT LIHUILI HOSPITACL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overexpression of miR-17-5p can inhibit the expression of many endoplasmic reticulum stress-related molecular chaperones and cause hERG translocation disorder

Method used

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  • Application of AMO-134 in preparation of medicine for treating arrhythmia
  • Application of AMO-134 in preparation of medicine for treating arrhythmia
  • Application of AMO-134 in preparation of medicine for treating arrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Materials and Methods

[0014] 1.1 Experimental instruments and reagents

[0015] 1.1.1 Main experimental instruments

[0016] Table 1 Names and manufacturers of experimental instruments

[0017]

[0018]

[0019] 1.1.2 Experimental drugs and reagents

[0020] Table 2 Names and manufacturers of experimental drugs

[0021]

[0022]

[0023] experimental method

[0024] 1.1.3

[0025] real-time fluorescent quantitative PCR

[0026] Total RNA was extracted from transfected U2OS cells with Trizol reagent. The RNA was subsequently treated with sterile RNase-free, and the level of hERG gene mRNA was assessed using Taqman probes and detected by qRT-PCR. Primers and probes are from ABI company cat.#4331182 (number: Hs04234270-g1). Reverse transcription conditions were set as an initial step at 95°C for 10 min, followed by 40 cycles of 95°C for 15 s and a hold at 60°C for 1 min. Real-time PCR reactions were performed in triplicate independently. The results...

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Abstract

The present invention discloses application of AMO-134 in preparation of a hERG expression promoting pharmaceutical composition for treating arrhythmia, and a pharmaceutical composition for treating arrhythmia, and the pharmaceutical composition is characterized by containing AMO-134.

Description

technical field [0001] The present invention relates to the application of AMO-134 in the preparation of drugs for treating arrhythmia, more specifically, the invention relates to the application of AMO-134 in the preparation of drugs for promoting hERG expression in the treatment of arrhythmia. Background technique [0002] Long QT syndrome is characterized by prolonged action potential repolarization and prolonged QT interval on the electrocardiogram, which can lead to increased torsades de pointes and predispose to sudden cardiac death. Although Na + and Ca 2+ Mutations in channel genes can lead to hereditary long QT syndrome, but hereditary long QT syndrome caused by functional defects of potassium channels caused by hERG gene mutations is more common. In addition, acquired long QT syndrome can be induced by many drugs such as class III antiarrhythmic drugs, and it is more common clinically. So far, 13 genes have been found to be related to hereditary long QT syndrome...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K31/713A61P9/06
Inventor 廉姜芳周建庆毛海燕巴艳娜庄凯丽
Owner NINGBO MEDICAL CENT LIHUILI HOSPITACL
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