Combinations for the treatment of cancer comprising an MPS-1 kinase inhibitor and a mitotic inhibitor
A mitosis and inhibitor technology, applied in the direction of drug combination, organic active ingredients, heavy metal active ingredients, etc., can solve the problems of accelerating cells, cell death, and anti-mitotic drugs stagnating mitosis.
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[0029] According to a first aspect, the present invention relates to a combination comprising an Mps-1 kinase inhibitor and one or more mitotic inhibitors.
[0030] The Mps-1 kinase inhibitor is selected from compounds of formula (I):
[0031]
[0032] in:
[0033] R 1 express
[0034]
[0035] where * indicates the point of attachment of said group to the rest of the molecule;
[0036] R 2 express
[0037]
[0038] where * indicates the point of attachment of said group to the rest of the molecule;
[0039] R 3 Represents a group selected from: methyl-, HO-CH 2 -, H 2 N-CH 2 -, -NH 2 ;
[0040] R 4 represents a group selected from: methoxy-, F 3 C-CH 2 -O-;
[0041] and
[0042] R 5 represents a group selected from:
[0043] h 3 C-S(O) 2 -, H 2 N-C(O)-, (CH 3 ) 2 N-C(O)-,
[0044]
[0045] or a hydrate, solvate or salt thereof, or a mixture thereof.
[0046] In a preferred embodiment, R 3 denotes a methyl-group.
[0047] In another preferr...
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