A gamma delta T cell surface activation molecule and kit for rapid diagnosis of active tuberculosis

Abstract

The invention discloses a gamma delta T cell surface-active molecule and a kit for quickly diagnosing active tuberculosis. According to the gamma delta T cell surface-active molecule and the kit disclosed by the invention, a specific T cell surface molecule is applied to the diagnosis of active tuberculosis for the first time; the gamma delta T cell surface-active molecule comprises a myeloid cell induced receptor 1 and / or a V delta 2T cell receptor; by using the two cell surface molecules and corresponding kits thereof, quick detection of active tuberculosis can be realized; the detection method and the detection kit of active tuberculosis have the advantages of high sensitivity, good specificity, simple operation, simplicity, convenience, quickness and the like; meanwhile, the detection method and the detection kit are low in price and are suitable for popularization and application.

Description

technical field

[0001] The invention specifically relates to a gamma delta T cell surface activation molecule and a kit for rapidly diagnosing active tuberculosis. Background technique

[0002] The gold standard for TB diagnosis is bacteriological examination, including acid-fast staining of sputum smear and isolation and culture of Mycobacterium tuberculosis. However, among tuberculosis patients, the detection rate of Mycobacterium tuberculosis is only 30%, which means that most of the patients are bacillus-negative tuberculosis, and it is difficult to obtain a diagnosis from etiology. At present, the laboratory diagnosis of bacillary negative tuberculosis largely relies on immunological detection methods. Traditional tuberculosis immunological detection methods include tuberculin test (TST) and serum tuberculosis antibody detection. TST uses tuberculin pure protein derivative (PPD) as an antigen to detect whether the body has been infected with Mycobacterium tuberculosis...

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