Nanometer level three-dimension magnetic resonance molecule imaging device based on diamond NV-color center

An imaging device and molecular imaging technology, which are applied in the directions of using nuclear magnetic resonance imaging system for measurement, magnetic resonance measurement, and magnetic variable measurement, etc., and can solve problems such as difficulty in applying microscale imaging.

Inactive Publication Date: 2016-07-06
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

[0002] The existing magnetic resonance imaging technology is difficult to apply to the field of micro-scale imaging due to the limitation of detection resolution or detection sensitivity

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  • Nanometer level three-dimension magnetic resonance molecule imaging device based on diamond NV-color center

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Embodiment Construction

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] like figure 1 As shown, the present invention proposes a diamond-based NV - The color center nanoscale three-dimensional magnetic resonance molecular imaging device includes: glass cube base 1, 532nm laser 2, diamond containing NV-color center 3, sample carrier 4, microwave pulser 5, microscope objective lens 6, monochromatic filter 7 , nano-convex lens 8, 360° rotating bias magnetic field 9, distributed optical imaging lens 10, polarized magnetic fiel...

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Abstract

The invention discloses a diamond-based NV ‑ A nanoscale three-dimensional magnetic resonance molecular imaging device for color centers, comprising: a glass base; a laser, arranged inside the glass base, for emitting laser light to the outside; containing NV ‑ The diamond with the color center is arranged on the upper surface of the glass base, and the laser emitted by the laser is directly irradiated to the diamond; the microwave pulser is used to input microwave pulses to the diamond; the microscope objective lens is used to make the NV of the diamond ‑ Fluorescence from the color center is emitted outward through the microscope objective; a monochromatic filter for filtering the NV of the diamond ‑ Fluorescence from color centers; nanoconvex lenses that filter the NV of the diamond ‑ The fluorescence emitted by the color center is further concentrated; the distributed optical imaging lens is used to realize the imaging function; the packaging device is used to realize the functions of stable temperature, electromagnetic shielding and isolation protection.

Description

technical field [0001] The invention relates to nuclear magnetic resonance technology, in particular to a diamond-based NV - The nanoscale three-dimensional magnetic resonance imaging device of the color center chip realizes nanoscale three-dimensional ultra-precise magnetic field imaging at the molecular, protein and cell levels. Background technique [0002] Due to the limitation of detection resolution or detection sensitivity, the existing magnetic resonance imaging technology is difficult to be applied to the field of micro-scale imaging. Nanoscale resolution imaging of objects has become an important requirement in the development of chemistry, physics and biomedicine. Since the magnetic field of a single proton is very weak, and its magnetic field strength is only 6nT at a distance of 10nm, it is a difficult problem for the scientific community to use what kind of sensor can be so close to the measured object and have such high sensitivity. [0003] Diamond NV - Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/48
CPCG01R33/48
Inventor 申宝忠
Owner HARBIN MEDICAL UNIVERSITY
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