High-precision blood sugar test paper with hematokrit measurement and compensation function

Abstract

The invention relates to a high-precision blood sugar test paper with a hematokrit measurement and compensation function. The high-precision blood sugar test paper comprises a substrate layer, the lower end of the substrate layer is provided with a first electrode, the lower end of the first electrode is provided with a corresponding second electrode, a work electrode is arranged between the first electrode and the second electrode, a communication electrode is arranged between the work electrode and the second electrode, the communication electrode is connected to the second electrode, the front end of the second electrode is provided with a covering layer, the rear end of the second electrode is provided with an upper partition sheet, the upper end of the covering layer is provided with an opening, a pore is arranged between the opening and a trigger electrode and an enzyme layer is arranged between the opening and the trigger electrode. Two reaction chambers are used and are filled with blood, hematokrit of the blood in one of the reaction chambers is measured by a conductivity method, a blood sugar concentration of the blood in the other of the reaction chambers is measured, and through HCT measurement, a blood sugar concentration measured value is subjected to dynamic calibration so that a high-accuracy measured blood sugar value is obtained. The trigger electrode prevents blood sugar measurement inaccuracy caused by underfill of the reaction chamber with blood.

Description

technical field [0001] The invention belongs to the technical field of biological sensing, in particular to a high-precision blood sugar test strip with hematocrit measurement and compensation. Background technique [0002] At present, the blood glucose test strips on the market generally adopt the electrochemical method, which is converted into the monitoring of the blood glucose concentration in the blood through the current measurement produced by the enzyme catalyzed glucose. However, the current blood glucose test strips on the market hardly consider the effect of hematocrit on the measurement of whole blood glucose. Changes in red blood cells can have a significant effect on whole blood glucose measurements, even more so than any other factor in some circumstances. At present, the measurement error of blood glucose test strips is less than 20% according to the Chinese national standard. However, when measuring blood glucose concentrations near 35% or more than 55% of...

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Problems solved by technology

The second is that the thickness of the diffusion layer directly affects the signal-concentration relationship of the detector. When the diffusion layer is large enough, it means that the diffusion control membrane is ineffective, and the rate of entering the reaction layer is too high to obtain a steady-state signal.

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