Kit for predicting recurrence and transference risk of patient suffering from early-stage operable esophageal squamous carcinoma
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A technology of esophageal squamous cell carcinoma and a kit is applied in the field of kits for predicting the risk of recurrence and metastasis in patients with early-stage operable esophageal squamous cell carcinoma, which can solve the problem that it is difficult to reflect the complex metastasis process and cannot fully reflect the molecular biological characteristics of early esophageal squamous cell carcinoma. and other problems to achieve the effect of improving prognosis and reducing recurrence
Inactive Publication Date: 2017-03-15
JIANGSU PROVINCE HOSPITAL
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However, there are multiple groups of genes involved in the regulation of the biological characteristics of tumors. At present, most studies focus on single-factor research models, only exploring the correlation between one or a few genes and prognosis, which cannot fully reflect the accurate molecular biology of early esophageal squamous cell carcinoma. characteristics, it is difficult to reflect the complex transfer process
Therefore, there is no index at home and abroad that can be used clinically to predict and diagnose the metastasis and recurrence of early-stage esophageal squamous cell carcinoma.
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[0032] The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, it should be understood that the described embodiments are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solution can be modified or replaced without departing from the spirit of the present invention, but these modifications or replacements all fall within the protection scope of the present invention.
[0033] A kit for predicting and evaluating the risk of metastasis and recurrence in patients after esophageal squamous cell carcinoma surgery. There are 32 tubes of reaction solutions for different genes, and each tube includes other required fluorescent quantitative PCR reaction systems except cDNA.
[0034] Patient Jiang, ma...
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Abstract
The invention provides a kit for predicting recurrence and transference risk of a patient suffering from early-stage operable esophageal squamous carcinoma. The kit contains amplification primers of 32 genes of BCL2, Survivin, STAT3, cIAP1, cIAP2, beta-catenin, Cyclin D1, CDKN2A, TCF4, EGFR, HER-2, AREG, EREG, TFPI-2, WNT1, BMI-1, MTOR, ATM, ATR, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, HIF-1alpha, HIF-2alpha, VEGF, RAD51, beta-actin, GAPDH, GUS and TFRC in all. The kit is capable of accurately predicting transference potential of early-stage operable esophageal squamous carcinoma, so that the transference and recurrence risk of the patient suffering from the early-stage operable esophageal squamous carcinoma after radical operation can be accurately predicted and evaluated, patients with high risk can be particularly monitored and effectively interfered, recurrence and transference of esophageal squamous carcinoma can be reduced, and prognosis of the patients can be further improved.
Description
technical field [0001] The invention belongs to the technical field of medical detection reagents, and specifically relates to a kit for predicting the risk of recurrence and metastasis of patients with early operable esophageal squamous cell carcinoma and the application of amplification primers for 32 genes. Background technique [0002] Esophageal cancer is one of the most common malignant tumors in my country, and about 95% of them are squamous cell carcinomas. According to NCCN guidelines, the standard treatment for early esophageal squamous cell carcinoma (T1-2N0M0) is surgical resection. Although the 5-year survival rate after surgical treatment for early esophageal squamous cell carcinoma can reach more than 90%, some patients still have early lymph node metastasis and local recurrence, showing a poor prognosis. Therefore, to predict lymph node metastasis and recurrence in patients with early-stage esophageal squamous cell carcinoma. [0003] With the advancement o...
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