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Peste des petits ruminants-goat pox bivalent live vaccine and production method thereof

A technology for Peste des petits ruminants and goat pox, which is applied to veterinary vaccines, biochemical equipment and methods, vaccines, etc., and can solve problems such as inconvenient use and interference of immune antigen components

Active Publication Date: 2017-06-13
CHINA INST OF VETERINARY DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] At present, there are live Peste des petits ruminants vaccines and goat pox live vaccines on the market, which need to be injected several times separately, which is inconvenient to use. Although the multiple vaccines are more convenient to use, the immune antigen components of the vaccine often cause interference

Method used

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  • Peste des petits ruminants-goat pox bivalent live vaccine and production method thereof
  • Peste des petits ruminants-goat pox bivalent live vaccine and production method thereof
  • Peste des petits ruminants-goat pox bivalent live vaccine and production method thereof

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Embodiment Construction

[0021] 1. Preparation of Peste des petits ruminants and goat pox dual live vaccine

[0022] (1) The basic seed virus for production of Peste des petits ruminant virus 75 / 1-Clone 9 strain (CGMCC No.13388) and the basic seed virus for production of goat pox virus temperature-sensitive attenuated strain (CVCC AV41) are both provided by China Prepared and supplied by the Veterinary Drug Control Institute.

[0023] (2) Production cells Vero cells: preserved by the China Veterinary Drug Control Institute (CVCC CL 28); goat kidney primary (secondary) cells: prepared from fresh goat kidneys, prepared and provided by the China Veterinary Drug Control Institute.

[0024] (3) Preparation of Peste des petits ruminants virus liquid After the PPRV 75 / 1-Clone 9 strain virus seed was hydrated with serum-free MEM, Vero cell suspensions with different cell concentrations were inoculated synchronously at 0.1%, 0.5%, 1%, and 2%. solution, and the concentration of cell suspension was adjusted to ...

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Abstract

The present invention relates to a Peste des petits ruminants-goat pox bivalent live vaccine and a production method thereof. According to the present invention, a Peste des petits ruminants virus PPRV 75 / 1-Clone 9 strain (CGMCC No.13388) and a goat pox virus temperature sensitive attenuated strain (CVCC No.AV41) are used as vaccine production strains and are respectively cultured in Vero cells and goat kidney primary (secondary) cells to harvest virus liquids, the virus liquids are mixed, a freeze drying protection agent is added to the mixed virus liquid, and vacuum freeze drying is performed to prepare the bivalent live vaccine for effectively preventing Peste des petits ruminants and goat pox.

Description

technical field [0001] The invention relates to a live vaccine for Peste des petits ruminants and goat pox and a production method thereof. It belongs to the field of veterinary biological products. Background technique [0002] Peste des petits ruminants and goat pox are two contagious diseases of goats. [0003] Peste des petits ruminants (PPR), also known as pseudorinderpest in small ruminants, catarrh, pneumoenteritis, and pneumonitis and enteritis syndrome, is a small disease caused by peste des petits ruminants (PPRV). An acute infectious disease of ruminants. The Food and Agriculture Organization of the United Nations (FAO) and the International Veterinary Bureau (OIE) both classify this disease as a severe infectious disease of class A, and this disease is also listed as a class of animal infectious disease in my country. [0004] In 1942, PPR was reported for the first time in Côte d'Ivoire, West Africa. In the following years, the disease was reported in Africa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/155A61K39/275A61K39/295A61K9/19A61K47/42A61K47/26A61K47/02A61P31/14A61P31/20
CPCA61K9/19A61K39/12A61K47/02A61K47/26A61K47/42A61K2039/552A61K2039/70C12N2710/24234C12N2760/18434A61K2300/00
Inventor 薛青红印春生孙淼张广川支海兵
Owner CHINA INST OF VETERINARY DRUG CONTROL
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