Device and method for epigenetic analysis

Abstract

The invention discloses a device for epigenetic analysis in the technical field of epigenetics, which includes a box body, the inner cavity of the box body is provided with a channel, and the top of the inner cavity of the channel is provided with a light source device. The bottom of the inner cavity of the channel is provided with a contact device, the left and right sides of the top of the box are respectively provided with a controller and a display screen, the left side of the box is provided with a laser, and the controller is respectively connected to the light source device and the contact screen. The device, the display screen and the laser are electrically connected. This kind of equipment and method for epigenetic analysis has a simple structure. It adds a whole genome analysis or a study of investigating more than two epigenetic marks, and provides a more reliable global analysis. The alternative method of genomic epigenetic analysis meets the needs of the composition, greatly reduces the cost, and enables people to better conduct further research on epigenetics.

Description

technical field [0001] The invention relates to the technical field of epigenetics, in particular to a device and method for epigenetic analysis. Background technique [0002] Epigenetics refers to heritable changes in gene expression that do not change in DNA sequence. This change is a change in the heritable material other than genetic information in the cell, and this change can be stably transmitted during development and cell proliferation. Current methods for epigenetic testing involve whole molecule analysis. Results represent a composite signal from multiple copies of genetic material, unlike single-molecule analyses. Histone modifications are commonly probed using chromatin immunoprecipitation (ChIP), in which modification-specific antibodies are used to immunoprecipitate associated DNA, which is then detected by hybridization to microarrays (Ren et al. (2000) Science, 290 , 2306-2309) (ChIP-ChIP) or deep sequencing (Barski et al. (2007) Cell, 129, 823-837) (ChIP...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a device and method for epigenetic analysis to solve the problem that the techniques proposed in the above background art cannot withstand whole genome analysis or investigation of more than two kinds of epigenetic marks, full analysis The technical report is the average value of the population and does not take into account the problem of variation at the single-molecule level

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