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Calibration method of thromboelastography

A technique for a thromboelastometry instrument and a calibration method, which is applied in the field of clinical coagulation testing instrument calibration, can solve the problems of deviation of the measured value of the thromboelastometry instrument and exceeds the normal range, etc., and achieves the effects of high calibration accuracy and perfect calibration process.

Active Publication Date: 2019-07-09
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

However, with the passage of time or changes in instrument parts, the measured value of the thromboelastography instrument may have a large deviation, beyond the normal range. At this time, it is necessary to calibrate the instrument with a calibrator

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  • Calibration method of thromboelastography
  • Calibration method of thromboelastography
  • Calibration method of thromboelastography

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0023] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0024] The invention provides a method for calibrating a thrombelastograph using fibrinogen as a calibrator, comprising the following steps:

[0025] S10, prepare buffer solution: prepare a mixed solution including Tris, NaCl, and CaCl2, and add hydrochloric acid to the mixed solution to adjust the pH to 7.0-8.0.

[0026] S20, prepare thrombin and different concentrations of fibrinogen according to the buffer solution;

[0027] S30, measure standard MA value and calibrated MA value: add thrombin and fibrinogen to the standard thrombelastograph and the thrombelastograph to be calib...

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Abstract

The invention discloses a calibration method of thromboelastography instruments. The method comprises the steps of preparing a buffer solution, namely preparing a mixed solution comprising Tris, NaCl and CaCl2 and adding hydrochloric acid to the mixed solution to adjust the pH to be 7.0-8.0; preparing thrombin and fibrinogens of different concentration according to the buffer solution; testing standard MA values and calibrated MA values, namely successively adding the thrombin and the fibrinogens to a standard thromboelastography instrument and a to-be-calibrated thromboelastography instrument separately and testing the standard MA values and the calibrated MA values of the fibrinogens of different concentration; and calculating a collaboration coefficient for correcting real-time measurement of the calibrated thromboelastography instrument according to the calibrated MA values and the standard MA values. According to the calibration method for thromboelastography instruments, the property that the fibrinogens are solidified under the action of the thrombin is utilized and the fibrinogens are taken as a calibration product, so that the calibratin process is complete and the calibration accuracy is high.

Description

technical field [0001] The invention relates to the technical field of calibration of clinical coagulation testing instruments, and more specifically, the invention relates to a method for calibrating a thromboelastography instrument. Background technique [0002] Thromboelastography is a non-invasive diagnostic instrument that assists clinicians to make accurate judgments on the coagulation status of clinical patients by monitoring and analyzing the coagulation process of blood samples, and predicts clinical conditions based on coagulation evaluation results, such as postoperative bleeding , Thrombosis during or after cardiac surgery, Thrombosis during or after organ transplantation, trauma, and cardiac surgery. [0003] As the role of thromboelastography in clinical practice becomes increasingly prominent, the accuracy, repeatability and stability of thromboelastography are particularly important. At present, normal plasma and abnormal plasma are mainly used clinically fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48
CPCG01N33/48
Inventor 梁伟国陈奕博王弼陡孙海旋缪鹏钱俊杨维
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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