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Probiotic composition at least comprising bifidobacterium bifidum W23 and capable of controlling intestinal barrier function

A composition and probiotic technology, applied in bifidobacterium, drug combination, function of food ingredients, etc., can solve problems such as research heterogeneity

Inactive Publication Date: 2017-12-01
WINCLOVE HLDG BV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A total of 29 studies were identified, but patients, bacterial characteristics and methods of measuring gut barrier function contributed to large heterogeneity among these studies

Method used

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  • Probiotic composition at least comprising bifidobacterium bifidum W23 and capable of controlling intestinal barrier function
  • Probiotic composition at least comprising bifidobacterium bifidum W23 and capable of controlling intestinal barrier function

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Embodiment Construction

[0020] Mental disorders, especially depression, are becoming a global epidemic. Worldwide, more than 350 million people of all ages suffer from depression. Various lifestyle and environmental changes may be responsible for the increased incidence of mental disorders. A particular area of ​​interest lies in the relationship between the gut microbiota and mental health.

[0021] gut microbiota

[0022] Although the internal environment of the human body is sterile, nearly all surface areas are colonized by microorganisms. Due to its open connection to the outside world, the gastrointestinal (GI) passage can be considered the largest surface area of ​​the human body (200m 2), which is about the size of a tennis court. Apart from its size, it is the area most densely colonized by microorganisms, in number (10 14 ) is 10 times larger than the number of somatic cells. The complex community of microorganisms that inhabit the gastrointestinal tract is known as the gut microbiota...

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Abstract

The invention relates to the field of medicine and nutrition, more specifically to the field of treatment and prevention of human disorders such as depression, rumination, aggression, migraine, autistic spectrum disorders (including autism and ADHD), schizophrenia, chronic fatique, kidney disorders, metabolic syndrome or diabetes type II. The invention provides a pharmaceutical or food composition or a supplement comprising a multispecies probiotic composition at least comprising Bifidobacterium bifidum W23 for use in the treatment or prevention of disorders in humans and methods to use such a pharmaceutical or food composition or a supplement.

Description

technical field [0001] The present invention relates to the fields of medicine and nutrition, and more particularly, to the field of treatment and prevention of human diseases involving the brain-gut axis, such as depression, rumination disorder, aggressive behavior, migraine, autism spectrum disorders (including loneliness and attention deficit hyperactivity disorder (ADHD), schizophrenia, chronic fatigue, and kidney disease, metabolic syndrome, or type 2 diabetes. Background technique [0002] The gut and brain are tightly connected by the brain-gut axis, which involves bi-directional communication through neural, endocrine, and immune pathways. In recent years, it has become increasingly apparent that this communication also involves interactions with the gut microbiota that release immune-activating molecules and other signaling molecules that regulate brain and play an important role in subsequent behavior. For example, the microbiota produces neuroactive substances a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61K35/745A61K35/747A61K31/405A61K35/744A23L33/135A23L33/175A61P25/24A61P25/06A61P25/18A61P25/00A61P3/10A61P13/12A61P39/00
CPCA23L33/175A23L33/135A61K31/405A61K35/741A61K35/744A61K35/745A61K35/747A61K2300/00A23V2002/00A61P13/12A61P25/00A61P25/06A61P25/18A61P25/24A61P39/00A61P3/10A23V2200/3204A23V2200/322A23V2400/517
Inventor 萨斯奇雅·范·赫默特
Owner WINCLOVE HLDG BV
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