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Molecular method for association detection of risk of nasopharyngeal carcinoma

A nasopharyngeal cancer and risk technology, which is applied in the field of nasopharyngeal cancer risk correlation detection, can solve problems related to tumor risk

Pending Publication Date: 2017-12-22
GUANGDONG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] To sum up, the problem existing in the prior art is that among the two sites rs2233678 (-842G>C) and rs2233679 (-667C>T) in the Pin1 promoter region, only one of them is associated with tumorigenesis risk related

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  • Molecular method for association detection of risk of nasopharyngeal carcinoma
  • Molecular method for association detection of risk of nasopharyngeal carcinoma
  • Molecular method for association detection of risk of nasopharyngeal carcinoma

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[0029] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0030] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0031] Such as figure 1 As shown, the molecular method for detecting the risk association of nasopharyngeal carcinoma provided by the embodiment of the present invention includes the following steps:

[0032] S101: Extraction of blood genome DNA;

[0033] S102: Restriction fragment length polymorphism (RFLP) method.

[0034] The application principle of the present invention will be further described in conjunction with experiments below.

[0035] 1. Case collection and grouping

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Abstract

The invention discloses a molecular method for association detection of the risk of nasopharyngeal carcinoma, belonging to the field of detection technology for nasopharyngeal carcinoma. The molecular method for association detection of the risks of nasopharyngeal carcinoma comprises the following steps: extraction of genomic DNAs in blood; treatment with PCR technology; and analysis of restriction fragment length polymorphisms. Discovery results in the invention show that two polymorphic sites, i.e., -842G>C(rs2233678) and -667C>T(rs2233679), of a Pin1 gene are associated with the risk of nasopharyngeal carcinoma in Guangdong Province, China; the Pin1 gene may be an important biomarker for the risk of nasopharyngeal carcinoma; and a Pin1 promoter can regulate the activity of a transcription factor AP2alpha.

Description

technical field [0001] The invention belongs to the technical field of detection of nasopharyngeal cancer incidence, and relates to a molecular method for detection of nasopharyngeal cancer incidence risk correlation. Background technique [0002] Peptide prolyl isomerase Pin1 is a highly conserved enzyme that specifically recognizes and binds protein phosphorylated silk / threoprolyl motifs. Pin1 is overexpressed in many tumor tissues and regulates the conformation of various cell cycle proteins, thereby regulating cell proliferation and differentiation. Through the regulation of various cellular pathways, such as cell growth, cell cycle, cell proliferation and differentiation, Pin1 plays a very important role in promoting the occurrence and development of tumors. Prostate cancer Pin1 acts on phosphorylated β-catenin to regulate cell adhesion and movement; in breast cancer Pin1 acts on phosphorylated cyclin D1 to regulate the cell cycle. In addition, Pin1 is associated with...

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/683C12Q1/6886C12Q2600/156C12Q2531/113C12Q2565/125C12Q2563/173
Inventor 何志巍黄国良
Owner GUANGDONG MEDICAL UNIV
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