Tuberculosis protein interacting with human protein nrf1 and its application

Abstract

The invention discloses tuberculosis protein interacting with human protein NRF1 and application thereof. The present invention provides the application of human protein NRF1 in any of the following: (A1) diagnosing tuberculosis; (A2) preparing a product for diagnosing tuberculosis. The invention utilizes the protein-protein interaction experiment based on the MTB Mycobacterium tuberculosis proteome chip to screen and identify, and obtain tuberculosis proteins Rv2239c, Rv0577, and Rv2499c interacting with human protein NRF1. The invention can be used for tuberculosis diagnosis or for regulating the activity of human protein NRF1.

Description

Technical field [0001] The present invention relates to the field of biotechnology, and more particularly to tuberculum proteins and their applications thereof in human protein NRF1. Background technique [0002] At present, the method of diagnosing tuberculosis is limited, but also lacks rapidly sensitive laboratory techniques, making it difficult to screen the latent infection of tuberculosis and early cases, it is difficult to make tuberculosis identification diagnosis, resulting in tuberculosis, diagnostic time prolonging or Diagnosis, difficulties in the diagnosis and treatment of tuberculosis. The main problem facing tuberculosis diagnosis is a rapid technology and method for diagnostic methods with low, long time, urgent tuberculosis diagnosis. There are many existing diagnostic methods that can only be used as a reference indicator of diagnosis, so that most tuberculosis patients cannot obtain early diagnosis, existing diagnostic methods do not meet the need for tuberculo...

AI Technical Summary

Problems solved by technology

[0002] At present, there are limited methods available for diagnosing tuberculosis, and at the same time, there is a lack of rapid and sensitive laboratory techniques, making it difficult to screen out latent infection cases and early cases of tuberculosis in time, and it is also difficult to conduct differential diagnosis of tuberculosis in time, resulting in missed diagnosis of tuberculosis patients, prolonged diagnosis time or Misdiagnosis brings difficulties to the diagnosis and treatment of various stages of tuberculosis

The main problems in the field of tuberculosis diagnosis are the low specificity and long time of diagnostic methods, and there is an urgent need for rapid technologies and methods for tuberculosis diagnosis

Many of the existing diagnostic methods can only be used as diagnostic reference indicators, so that most tuberculosis patients cannot obtain early diagnosis, and the existing diagnostic methods cannot meet the needs of tuberculosis prevention and control. Tuberculosis diagnostic methods and techniques

Bacteriology is the gold standard for diagnosing tuberculosis. However, Mycobacterium tuberculosis grows extremely slowly. It takes about two months for culture identification, and the positive rate depends on the number of bacteria in the collected specimens. The detection sensitivity is low, which is not conducive to the diagnosis of tuberculosis. with treatment

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