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Tuberculoproteins interacting with human proteins and application thereof

A technology of human protein, tuberculosis protein, applied in the field of tuberculosis protein

Active Publication Date: 2018-12-07
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mutation or loss of expression of SMAD2 can interrupt TGF-β signal transmission, causing cells to escape the growth inhibitory effect of TGF-β and leading to the occurrence and development of many tumors

Method used

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  • Tuberculoproteins interacting with human proteins and application thereof
  • Tuberculoproteins interacting with human proteins and application thereof
  • Tuberculoproteins interacting with human proteins and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1. Based on the protein-protein interaction experiment of MTB Mycobacterium tuberculosis proteome chip, the tuberculosis protein interacting with human protein SMAD2

[0036]MTB Mycobacterium tuberculosis proteome chip: company product: Guangzhou Bochong Biotechnology Co., Ltd., the article number is TB-10001-102988. The MTB Mycobacterium tuberculosis proteome chip contains 4262 Mycobacterium tuberculosis recombinant proteins, and is currently the world's first Mycobacterium tuberculosis proteome chip. The chip is suitable for global research on protein-protein interaction, protein-nucleic acid interaction, protein-small molecule interaction and protein post-translational modification, and is also suitable for systematically discovering autoantibodies in serum for diagnosis or other characterization research on markers.

[0037] 1. Technical route

[0038] Each sample was detected using 1 MTB protein chip. Samples are bound to proteins immobilized on the chip...

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PUM

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Abstract

The invention discloses tuberculoproteins interacting with human proteins and application thereof. The invention provides any one of the applications of human protein SMAD2: (A1), diagnosis of tuberculosis; (A2), preparation of a product for diagnosing tuberculosis. According to the tuberculoprotein interacting with the human protein and the application thereof, by utilizing protein-protein interaction experiment based on MTB mycobacterium tuberculosis aptamer-based proteomics arrays, screening and verification are carried out, and tuberculoproteins Rv2423, Rv3241c, Rv3153, Rv0577, Rv2499c and / or Rv2117 interacting with the human proteins are obtained. The tuberculoproteins can be applied to diagnosis of tuberculosis or regulation of activity of human protein SMAD2.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to tuberculosis protein interacting with human protein SMAD2 and application thereof. Background technique [0002] Tuberculosis is still one of the infectious diseases that seriously threaten human health, have the widest prevalence and the highest mortality rate. According to the World Health Organization, there are about 10 million new cases every year in the world, of which about 2 million people die from tuberculosis, and the death toll ranks first among single infectious diseases. At present, the early laboratory diagnosis methods are very limited. At the same time, due to the growth characteristics of Mycobacterium tuberculosis (MTB) and the widespread use of Bacillus Calmette-Guerin (BCG) inoculation in my country, these methods have their own shortcomings in the diagnosis of tuberculosis. The positive rate of acid-fast bacillus smear method is low, and the culture method of Myc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47G01N33/68G01N33/569
CPCC07K14/4702G01N33/5695G01N33/68G01N2333/35
Inventor 曹廷明吕翎娜张宗德
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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