Genetic marker group and individual gene identification card and application thereof

A genetic marker and ID card technology, applied in the field of genetic marker combination and individual gene ID card, can solve the problems of long period of STR typing experiment, and achieve the effect of economical and economical technology, simple technology and improved accuracy.

Inactive Publication Date: 2019-02-12
BEIJING USCI MEDICAL LAB CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to provide a combination of genetic markers, an individual genetic ID card and its application to solve the technical problem of using STR typing experiments in the prior art with a long cycle

Method used

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  • Genetic marker group and individual gene identification card and application thereof
  • Genetic marker group and individual gene identification card and application thereof
  • Genetic marker group and individual gene identification card and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0023] Multiple SNP sites are tagSNPs located in different haplotype regions, MAF is between 0.48 and 0.505, adjacent SNP sites have no linkage relationship, the distance between adjacent SNP sites is greater than 1M, and the variation information is not A / T Or C / G and SNPs are evenly distributed in all chromosomes. These rule inventions screen the SNP sites and optimize the screening. According to a typical embodiment of the present invention, the genetic marker combination includes the SNP positions shown in Table 1 below point:

[0024] Table 1

[0025] rs970973

rs10206850

rs1531545

rs12919

rs1891110

rs2159132

rs7278737

rs1874045

rs9646748

rs2548612

rs2301963

rs1025412

rs1292053

rs464663

rs7514102

rs3732083

rs2304054

rs1293288

rs4453265

rs1026128

rs4680

rs1801274

rs6756597

rs315717

rs1800392

rs1852450

rs1805034

rs2106416

rs2274064

rs6765537

rs1052486

rs4870723

...

Embodiment 1

[0036] The selected 66 SNP sites (as shown in Table 1), of which 64 are recorded in the UKBiobank (UK biological sample bank) The number and frequency of each SNP site and each genotype population are as follows in Table 2, from statistical analysis The probability of having the same genetic ID card is less than 4.50266E-20, which means that this method can be used to identify at least tens of billions of people.

[0037] Table 2

[0038]

[0039]

Embodiment 2

[0041] The actual sample typing was carried out on the sites shown in Table 1, and the typing results of 32 actual samples were shown in Table 3, and the results showed that the individuals could be completely distinguished.

[0042] table 3

[0043]

[0044]

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PUM

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Abstract

The invention discloses a genetic marker group and an individual gene identification card and application thereof. The genetic marker group comprises multiple SNP sites, wherein the multiple SNP sitesare tagSNPs located in different haplotype areas, the MAF is between 0.48 to 0.505, the adjacent SNP sites are not in linkage relationships, the distance among the adjacent SNP sites is larger than 1M, and variation information non A / T or C / G and the SNPs are evenly distributed in all chromosomes. By applying the technical scheme, through effective combination of the SNP sites, the set of genetic marker group which is simple in technology, economical and practical is formed, and can be used as the individual DNA identification card, and when the SNP sites are selected, linkage relationships,the MAF, distance, variation situations and the evenness of distribution on the chromosomes of the sites are taken into account, so that the accuracy of judging a certain gene sample is improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a combination of genetic markers, an individual genetic ID card and applications thereof. Background technique [0002] A common practice in judging whether a certain gene sample is a certain person in forensic identification is to select 13 to 21 STRs (short tandem repeats) with a relatively high degree of variability in the population for detection. However, there are many problems in STR typing technology, such as long experimental cycle, high technical requirements, relying on the principle of PCR amplification to increase the error of typing results, and it is not easy to digitize. Contents of the invention [0003] The invention aims to provide a combination of genetic markers, an individual genetic ID card and the application thereof, so as to solve the technical problem of the long cycle of STR typing experiments in the prior art. [0004] In order to achieve the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12N15/11
Inventor 张静波马劲枫李孟键王建伟刘倩唐宇
Owner BEIJING USCI MEDICAL LAB CO LTD
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