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Skin equivalents with distinct, juxtaposed dermal compartments

An equivalent and differentiated technology, applied in the same field, can solve the problems of heterogeneity, similarity of human skin, complex human skin, etc.

Active Publication Date: 2021-08-10
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, these conventional reconstructed skins are homogenous and not sufficiently similar to human skin, which is complex and heterogeneous

Method used

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  • Skin equivalents with distinct, juxtaposed dermal compartments
  • Skin equivalents with distinct, juxtaposed dermal compartments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0087] This example shows reconstructed skin alternating at the skin level with areas of papillary fibroblasts or reticular fibroblasts.

[0088] Preparation of dermal equivalents with three differentiated compartments

[0089] Two human fibroblast solutions, one containing papillary fibroblasts and the other containing reticular fibroblasts, were prepared at 2 × 10 in MEM 25 mM Hepes medium containing 10% FCS 6 The ratio of cells / ml was prepared.

[0090] From these fibroblast solutions, two different lattice preparation solutions were prepared, one (solution A) for the periphery of a 1.5 cm x 3.8 cm rectangular Teflon inclusion mold and the other (solution B) for Inside the mold.

[0091] Solution A contained 3.22ml MEM 1.76X medium, 0.63ml FXS, 0.35ml NaOH 0.1N, 0.2ml MEM25mM Hepes medium, 10% FCS and 0.5ml papillary fibroblast solution.

[0092] Solution B contained 3.22ml MEM 1.76X medium, 0.63ml FXS, 0.35ml NaOH 0.1N and 0.2ml MEM 25mM Hepes medium, 10% FCS and 0.5ml re...

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Abstract

The invention relates to a dermis equivalent comprising longitudinally at least two distinct, juxtaposed dermal compartments of different composition, and a skin equivalent comprising the dermis equivalent.

Description

technical field [0001] The present invention relates to novel skin equivalents with surface heterogeneity. Background technique [0002] Over the years, attempts have been made to develop reconstructed skin models that resemble human or animal skin as closely as possible, in order to avoid experimental testing on animals. [0003] Thus, dermal equivalents can be replicated by mixing collagen and fibroblasts under conditions that induce dermal tissue formation. This step can then be followed by skin reconstruction by allowing keratinocytes to grow on this matrix to produce the epidermis. [0004] However, these conventional reconstructed skins are homogeneous and not sufficiently similar to human skin, which is complex and heterogeneous. [0005] There is therefore a strong need for new reconstructed skin capable of reproducing the heterogeneous properties of skin. Contents of the invention [0006] The present invention fulfills this need. [0007] In fact, the invento...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60C12N5/071G01N33/50
CPCA61L27/60C12N2503/06G01N33/5088C12N5/0698C12Q1/025
Inventor D·阿塞利诺埃尔韦·派格昂西尔维·理奎斯
Owner LOREAL SA
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