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Application of HLA-DRB1*04:03 allele to evaluation of risk of occurrence of drug eruption caused by methimazole

A technology of HLA-DRB1, allele, applied in the direction of determination/inspection of microorganisms, biochemical equipment and methods, etc.

Active Publication Date: 2019-04-05
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] But so far, there is no reliable detection method that can predict the risk of drug eruption caused by methimazole

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] 1. Sample

[0034] Methimazole-induced drug eruption group (15 patients with methimazole-induced drug eruption, all volunteers with informed consent): the average age of the patients was 43.7±12.6 years, and 13 of them were female; the patients started taking methimazole orally The incubation period to the occurrence of drug eruption was 15.3±5.6 days; the oral dose of methimazole was 10mg-45mg; among the patients, 13 showed urticarial drug eruption, and 2 showed exanthematous drug eruption; among the patients, 5 patients Shortness of breath occurred during the onset.

[0035] Clinical control group (48 patients who received methimazole treatment for three months or more without any adverse reactions, all volunteers with informed consent): the average age of the patients was 44.2±14.9 years, and 32 of them were women.

[0036] The peripheral blood of each volunteer was collected, and the genomic DNA was extracted respectively.

[0037] 2. HLA genotyping

[0038] Take...

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PUM

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Abstract

The invention discloses application of HLA-DRB1*04:03 allele to evaluation of risk of occurrence of drug eruption caused by methimazole, discloses application of a material for detecting the HLA-DRB1*04:03 allele to preparation of a kit and also discloses a kit comprising the material for detecting the HLA-DRB1*04:03 allele. The kit has the functions of (a) evaluating the risk of occurrence of drug eruption caused by methimazole of testees, (b) evaluating the risk of occurrence of drug eruption caused by methimazole of the testees and showing that the risk of occurrence of drug eruption of thetestees carrying the HLA-DRB1*04:03 allele after taking methimazole is higher than that of the testees without carrying the HLA-DRB1*04:03 allele, (c) evaluating whether the testees are suitable fortaking methimazole and (d) evaluating whether the testees are suitable for taking methimazole and showing that the testees carrying the HLA-DRB1*04:03 allele are not suitable for taking methimazole.

Description

technical field [0001] The invention relates to the application of HLA-DRB1*04:03 allele in evaluating the risk of drug eruption caused by methimazole. Background technique [0002] Major histocompatibility complex (major histocompatibility complex, MHC) is a general term for all biocompatible complex antigens. MHC is not only related to transplant rejection, but also widely involved in the induction and regulation of immune responses. Human MHC is called human leukocyte antigen (Human leukocyte antigen, HLA). The HLA gene complex is located on the short arm of human chromosome 6 (6p21.3), with a length of about 3.6Mb and more than 200 gene loci. The main loci are HLA-A, HLA-B, HLA-C, HLA- DP, HLA-DQ and HLA-DR etc. are highly polymorphic. [0003] Drug eruption refers to the adverse reactions of the skin and (or) mucous membranes caused by drugs entering the human body through various channels. It is the most common adverse drug reaction, with a reported incidence of 1-3...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/106C12Q2600/172
Inventor 骆肖群邢清和熊浩朱沁媛叶红英
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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