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Application of GAS5 (growth arrest specific 5) in diagnosis of severe asthma

A technology for asthma and severe disease, applied in the application field of GAS5 in the diagnosis of severe asthma, can solve the problem of lack of mature methods for assessing glucocorticoid sensitivity of asthma patients, biomarkers and other problems

Pending Publication Date: 2019-09-06
CHANGZHOU NO 2 PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no mature methods and biomarkers for assessing the sensitivity of asthma patients to glucocorticoids. Finding biomarkers that can assess the sensitivity of glucocorticoids is of great significance for the early diagnosis and treatment of severe asthma patients

Method used

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  • Application of GAS5 (growth arrest specific 5) in diagnosis of severe asthma
  • Application of GAS5 (growth arrest specific 5) in diagnosis of severe asthma
  • Application of GAS5 (growth arrest specific 5) in diagnosis of severe asthma

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Example 1 Screening Gene Markers Related to Asthma

[0061] 1. Research object

[0062] a. Severe asthma group: 5 cases. The diagnostic criteria for severe asthma were based on the 2017 edition of the Chinese Expert Consensus on the Diagnosis and Treatment of Severe Asthma. The specific inclusion criteria are: ① no acute exacerbation of asthma within 1 month before enrollment; ② no hospitalization due to asthma in the past 1 month; ③ FEV1 ≥ 45% of predicted value, FEV1 ≥ 55% of predicted value after bronchodilator use; ④ daily Oral prednisolone dose <20mg; ⑤ no upper and lower respiratory tract infection in the past month; ⑥ non-smoking patients.

[0063] b. Common asthma group: 20 cases, the diagnostic criteria of asthma are based on the 2016 version of the guidelines for the prevention and treatment of bronchial asthma in my country. Positive bronchodilator test (FEV1% increase > 12%, and FEV1 absolute value increase > 200ml), or bronchial provocation test positive,...

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Abstract

The invention discloses application of GAS5 (growth arrest specific 5) in the diagnosis of severe asthma. It is discovered for the first time that GAS5 has a significant upregulation in severe asthma;whether a testee has severe asthma can be judged by detecting the expression level of GAS5. The invention also discloses a significant regulation of the expression level of GAS5 after glucocorticoiddrugs are applied to a severe asthma sample; whether the testee has severe asthma can be judged by detecting the expression level of GAS5 before and after the application of the glucocorticoid drugs;the problem of individual differences can be solved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of GAS5 in the diagnosis of severe asthma. Background technique [0002] Bronchial asthma (referred to as asthma) is a chronic airway inflammatory disease with heterogeneous characteristics in etiology, pathogenesis, clinical manifestations and outcomes (De Ferrari, L.; Chiappori, A.; Bagnasco, D., et al. al., Molecular phenotyping and biomarker development: are we on our way towards targeted therapy for severe asthma? Expert review of respiratory medicine 2016, 10(1), 29-38.). Severe asthma is a subtype of asthma and the main cause of disability and death from asthma. Epidemiological surveys in my country show that severe asthma accounts for about 5.99% of asthmatic patients over the age of 14. Although the proportion is not high, it leads to frequent emergency visits or hospitalization of patients, which seriously affects the quality of life and physical and mental heal...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158
Inventor 张倩吴迪蒋婷
Owner CHANGZHOU NO 2 PEOPLES HOSPITAL
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