Application of cytotoxic anti-tumor drugs to preparation of tumor-related tissues

An anti-tumor drug and tumor-related technology, applied in the application field of cytotoxic anti-tumor drugs in the preparation of tumor-related tissues, can solve problems such as limitations, and achieve the effect of promoting tumor growth or tumor cell proliferation
CN110694070AInactive Publication Date: 2020-01-17THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
Publication Date
2020-01-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides application of cytotoxic anti-tumor drugs to preparation of tumor-related tissues. A research proves that under a drug administration condition of certain concentration or dosage being less than conventional maximum tolerance dose, a result proves that the drugs have an effect of obviously promoting tumor growth; and by utilizing the phenomenon, the drugs can be applied to building of a tumor growth model, production culturing of in vitro and in vivo tumor tissues and tumor cells, culturing of tissue cells closely related with tumor tissue growth in a tumor micro-environment, and separation and extraction of specific tissue components.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to the application of cytotoxic antitumor drugs in preparing tumor-related tissues. Background technique

[0002] Malignant tumor is one of the most important diseases leading to human death. Tumor tissue is heterogeneous and consists of tumor cells, tumor stem cells, fibroblasts, endothelial cells, pericytes, lymphocytes, macrophages, and other types of bone marrow-derived cells and local tissue-derived cells. They interact and influence each other through direct effects or indirect pathways such as secreting cytokines, which jointly constitute the tumor microenvironment. In the tumor microenvironment, there are not only cells, cytokines and compound components that can promote tumor growth, but also cells, cytokines and compound components that inhibit tumor growth. The complex heterogeneity of tumor tissue is one of the important reasons why tumors are difficult to cure. However, some ...

Claims

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