Flow cell for the selective enrichment of target particles or cells

A technology of target cells and flow cells, applied in laboratory containers, preparation of test samples, fluid mixers, etc., can solve the problem of long separation time, hindering automatic optical detection and evaluation, and increasing the number of particle surface contacts And other issues

Active Publication Date: 2020-04-03
森泰克生物分析有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the separation time of this system is relatively long, and therefore it is only used to process a small number of samples
Additionally, none of the systems effectively increased the number of particle surface contacts
Additionally, barrier elements integrated on the chip or flow cell surface unduly hinder automated optical detection and evaluation, or even make them impossible

Method used

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  • Flow cell for the selective enrichment of target particles or cells
  • Flow cell for the selective enrichment of target particles or cells
  • Flow cell for the selective enrichment of target particles or cells

Examples

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Embodiment Construction

[0063] The present invention will now be described by way of example with reference to the accompanying drawings. figure 1 The microfluidic flow cell of the present invention is shown, comprising a top part (1) and a bottom part (2), which can cooperate with each other to form at least one meander-shaped flow channel. exist figure 1 In the example shown in , the bottom part is a glass slide coated with molecules that have an affinity for the target cells or particles to be isolated or enriched. Optionally, a sealing means (9) such as a rubber ring may be located between the top part (1) and the bottom part (2). When used in a microfluidic device, the top part (1) and the bottom part (2) of the flow cell are surrounded by upper (10) and lower (11) holding means ( 11) Shaped so that they surround and stabilize the assembly of the top part (1) and bottom part (2). The top part (1) comprises one or more flow channels etched or molded into the material of the top part.

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Abstract

The present invention relates to the field of micro fiuidics. Specifically, the present invention relates to a novel flow cell for the selective enrichment of target particles or cells from a fluid. The flow cell exhibits a novel design which greatly improves the target particle or cell yield. The invention also provides a micro fiuidic device, comprising the flow cell according to the invention.In another aspect, the invention relates to the use of a flow cell or a micro fiuidic device of the invention for the isolation of target particles or cells from a fluid sample. Finally, the inventionrelates to a method for the selective enrichment of target particles or cells from a fluid using the flow cell of the invention.

Description

technical field [0001] The present invention relates to the field of microfluidics. In particular, the present invention relates to a novel flow cell for the selective enrichment of target particles or cells from a fluid. The flow cell exhibits a novel design that greatly improves target particle or cell yield. The invention also provides a microfluidic device comprising a flow cell according to the invention. In another aspect, the invention relates to the use of the flow cell or microfluidic device of the invention for isolating particles or cells of interest from a fluid sample. Finally, the invention relates to a method for the selective enrichment of target particles or cells from a fluid using the flow cell of the invention. Background technique [0002] Reliable detection of rare cells in fluids is important in different practical fields. For example, the detection and quantification of pathogenic bacteria in drinking water is extremely important. Another example...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01F13/00B01F5/06G01N1/34
CPCB01L3/502707B01L3/50273B01L3/502761B01L2200/0631B01L2200/0647B01L2200/0652B01L2200/0668B01L2200/12B01L2300/0681B01L2300/0851B01L2300/0858B01L2300/088B01L2300/0883G01N1/405G01N2001/4088B01F25/4233B01F25/4231B01F25/4332B01F25/4331B01F33/30B01F35/512B01L2300/0877B01L2300/12B01F2101/2202
Inventor E.T.格迪希M.迪克曼
Owner 森泰克生物分析有限责任公司
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