Method and device for constructing genetic subtype prediction model and computer equipment

A technique for predicting models and testing samples, which is applied in the field of building genetic subtype prediction models, and can solve problems such as poor flexibility, narrow application range of genetic subtype prediction models, and inability to guarantee representative correspondence.

Pending Publication Date: 2020-05-12
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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Problems solved by technology

[0002] In traditional techniques, cytogenetic abnormalities can be determined based on characteristics such as gene expression levels, immunophenotypes, or fluorescence in situ hybridization, and then the corresponding relationship between the above characteristics and genetic subtypes can be obtained by analyzing multiple cases, and genetic subtypes can be constructed. However, this correspondence is simply to match the above characteristics of the case with the genetic subtype, which is less flexible and cannot guarantee that a representative correspondence can be extracted from it, resulting in the scope of application of the genetic subtype prediction model. narrow

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  • Method and device for constructing genetic subtype prediction model and computer equipment
  • Method and device for constructing genetic subtype prediction model and computer equipment
  • Method and device for constructing genetic subtype prediction model and computer equipment

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[0052] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0053] Reference herein to an "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The occurrences of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiment...

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Abstract

The invention relates to a method and device for constructing a genetic subtype prediction model, computer equipment and a storage medium. The method comprises the following steps: receiving a gene expression profile of a training sample and a corresponding genetic subtype; according to a predetermined classification number, performing classification integration on the gene expression profile to obtain a target gene expression profile, wherein the target gene expression profile comprises categories corresponding to the number of the categories; selecting a target category from the categories of the target gene expression profile, and constructing a corresponding relation between the target category and the genetic subtype; and outputting a genetic subtype prediction model according to thecorresponding relation. By adopting the method, the genetic subtype prediction model can be obtained on the basis of a flexible corresponding relation constructed between the gene expression profile and the genetic subtype.

Description

technical field [0001] The present application relates to the field of biotechnology, in particular to a method, device, computer equipment and storage medium for constructing a genetic subtype prediction model. Background technique [0002] In traditional techniques, cytogenetic abnormalities can be determined based on characteristics such as gene expression levels, immunophenotypes, or fluorescence in situ hybridization, and then the corresponding relationship between the above characteristics and genetic subtypes can be obtained by analyzing multiple cases, and genetic subtypes can be constructed. However, this correspondence is simply to match the above characteristics of the case with the genetic subtype, which is less flexible and cannot guarantee that a representative correspondence can be extracted from it, resulting in the scope of application of the genetic subtype prediction model. narrow. With the development of biotechnology, the study of organisms can go deep ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/40G16B25/10G16B40/20
CPCG16B20/40G16B25/10G16B40/20
Inventor 黄庆生梁会营钟嘉泳高欢李宽荣
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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