Dark-field microscope apparatus utilizing portable electronic communication device

A communication device and dark field technology, applied in microscopes, measuring devices, condensers, etc., can solve problems such as barriers to use, little progress in DFM image analysis, and lack of portability, and achieve reproducible stability, light weight, and portability Effect

Active Publication Date: 2020-05-15
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The size, cost, and delicate features of conventional DFM systems limit their utility in non-laboratory settings such as field hospitals and other settings, where these factors represent barriers to their use
In addition to its lack of portability, conventional DFM systems may also be limited in their ease of use
[0009] Attempts to develop more portable DFM methods date back to 1958, when dermatologists used DFM image analysis to diagnose agents responsible for the treatment of a variety of diseases that produce skin lesions, including syphilis, but these devices became obsolete while other technologies were developed, and Since then, little progress has been made in DFM image analysis

Method used

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  • Dark-field microscope apparatus utilizing portable electronic communication device
  • Dark-field microscope apparatus utilizing portable electronic communication device
  • Dark-field microscope apparatus utilizing portable electronic communication device

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Embodiment Construction

[0059] The embodiments set forth below represent the necessary information to enable one skilled in the art to practice the embodiments and demonstrate the best mode for practicing the embodiments. After reading the following description in light of the accompanying drawing figures, those skilled in the art will understand the concepts of the disclosure and will recognize applications of these concepts not particularly addressed herein. It should be understood that these concepts and applications fall within the scope of this disclosure and the appended claims.

[0060] It will be understood that, although the terms first, second etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, without departing from the scope of the present d...

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Abstract

A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 542,980, filed August 9, 2017, the entire contents of which are incorporated herein by reference. [0003] Government Rights in This Invention [0004] This invention was made with Government support under R01 AI113725 and R01 AI122932 awarded by the National Institutes of Health. The Government has certain rights in this invention. technical field [0005] The present disclosure relates to dark field microscopy devices and methods of using such devices for quantitative biological research, including (but not limited to) dark field microscopy devices and nanoparticles (e.g., gold nanoparticles) suitable for quantitatively providing a scattering signal. or silver nanoparticles, such as nanorods) to generate nanoparticle signals. Background technique [0006] Gold nanoparticles have become popular labeling agents for detection and quanti...

Claims

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Application Information

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IPC IPC(8): G02B21/10G02B21/02G02B21/26G02B13/00G02B19/00G01N21/01G01N33/58
CPCG02B21/10G01N33/587G01N21/51G01N2201/0221G02B21/34G02B21/0008G02B21/025G02B21/26
Inventor胡晔孙大利
OwnerTHE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA