Automatic slice reading method and automatic slice reading system for PD-L1 antibody staining slices

A PD-L1, antibody technology, applied in the field of data processing, can solve the problems of inconvenience and large reading labor, and achieve the effect of fast analysis and reduced reading labor.

Active Publication Date: 2020-06-05
BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the quantitative analysis of PD-L1 immunohistochemical staining sections is mainly carried out manually, and it is inconvenient for doctors to read the slides with a large amount of labor.

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  • Automatic slice reading method and automatic slice reading system for PD-L1 antibody staining slices
  • Automatic slice reading method and automatic slice reading system for PD-L1 antibody staining slices
  • Automatic slice reading method and automatic slice reading system for PD-L1 antibody staining slices

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Embodiment Construction

[0058] The technical solutions in the present disclosure will be clearly and completely described below in conjunction with the drawings in the present disclosure. Obviously, the described embodiments are only some of the embodiments of the present disclosure, not all of them. The components of the present disclosure generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations. Accordingly, the following detailed description of the embodiments of the present disclosure provided in the accompanying drawings is not intended to limit the scope of the claimed disclosure, but merely represents selected embodiments of the present disclosure. Based on the embodiments of the present disclosure, all other embodiments obtained by those skilled in the art without creative effort shall fall within the protection scope of the present disclosure.

[0059] It should be noted that like numerals and letters denote similar items...

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Abstract

The invention provides an automatic slice reading method and an automatic slice reading system for PD-L1 antibody staining slices. The automatic slice reading of PD-L1 immunohistochemical staining slices is realized based on medical digital image analysis and processing. Specifically, the method disclosed by the invention comprises the following steps: preprocessing a PD-L1 dyed digital slice image; obtaining an image to be analyzed, inputting the to-be-analyzed image into a pre-established prediction model; obtaining a target area corresponding to set cells in the to-be-analyzed image; and carrying out image analysis on the cell image of each set cell in the target area, identifying the total number of cells in the target area and the number of cells with positive slice formation, obtaining the proportion of the cells with positive slice formation in the target area, and finally realizing rapid, accurate and automatic slice reading of the set cells.

Description

technical field [0001] The present disclosure relates to the technical field of data processing, in particular, to an automatic reading method and system for PD-L1 antibody stained sections based on medical digital image analysis and processing. Background technique [0002] With the rise of immunotherapy, corresponding drugs have been produced targeting PD-L1 protein in the immune signaling pathway, such as Atezolizumab, Pembrolizumab, Nivolumab, etc. While improving the therapeutic effect, higher requirements are put forward for the quantitative analysis of PD-L1 immunohistochemically stained sections. At present, the quantitative analysis of PD-L1 immunohistochemical staining sections is mainly carried out manually, which requires a large amount of labor for doctors to read the slides and is inconvenient to implement. Contents of the invention [0003] The present disclosure provides an automatic reading method and system for PD-L1 antibody stained sections. [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/11G06T7/90G06M11/00G01N21/84
CPCG06T7/11G06T7/90G06M11/00G01N21/84G06T2207/10056G06T2207/30024G06T2207/30242Y02A90/10
Inventor 刘小晴吴江华孙巍林冬梅刘昌灵张军杰凌少平
Owner BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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