A method for improving the survival of a subject with
cancer is disclosed, comprising applying an alternating
electric field having a predetermined frequency and
electric field intensity to a
target site of the subject containing one or more
cancer cells for a predetermined period of time, and administering the subject a therapeutically effective amount of a checkpoint inhibitor. A method for treating a subject with
cancer is disclosed, comprising applying an alternating
electric field having a predetermined frequency and electric
field intensity to a
target site of the subject containing one or more cancer cells for a predetermined period of time, and administering the subject a therapeutically effective amount of a checkpoint inhibitor. In some embodiments, the checkpoint inhibitor is nivolumab, pembrolizumab, or
atezolizumab. Furthermore, a method for improving the survival of a subject with non-
small cell lung cancer is disclosed, comprising applying an alternating electric field having a predetermined frequency and electric
field intensity to a
target site of the subject containing one or more non-
small cell lung cancer cells for a predetermined period of time, and administering the subject a therapeutically effective amount of a checkpoint inhibitor. A method for treating a subject having non-
small cell lung cancer is disclosed, the method comprising applying an alternating electric field having a predetermined frequency and electric
field intensity to a target site of the subject containing one or more non-small
cell lung cancer cells for a predetermined period of time, and administering to the subject a therapeutically effective amount of a checkpoint inhibitor. In some embodiments, the checkpoint inhibitor is ipilimumab (Yervoy), pembrolizumab (Keytruda), nivolumab (Opdivo), semiprimab (brand name Ributayo), dostallimab (Jemperli),
atezolizumab (Tecentriq), durvalumab (Imfinzi), or avelumab (Bavencio).