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Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy

A nanoparticle and inhibitor technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem of death of patients with advanced diseases

Pending Publication Date: 2020-09-18
ABRAXIS BIOSCI LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although therapeutic advances in CRC have had a major impact on its management, many patients with advanced disease will eventually succumb to their cancer

Method used

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  • Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy
  • Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy
  • Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0365] Embodiment 1. A method of treating colon cancer in an individual, comprising administering to the individual; a) an effective amount of a nanoparticle-containing composition comprising an mTOR inhibitor and albumin; b) an effective amount of an anti-VEGF antibody ; C) A therapeutically effective FOLFOX regimen.

Embodiment approach 2

[0366] Embodiment 2. The method of embodiment 1, wherein the colon cancer includes abnormal mTOR activation.

Embodiment approach 3

[0367] Embodiment 3. The method of embodiment 2, wherein the abnormal mTOR activation includes abnormal PTEN.

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Abstract

The present application provides methods of treating a colon cancer (such as advanced and / or metastatic colon cancer) in an individual, comprising administering to the individual: a) an effective amount of a composition comprising nanoparticies comprising an mTOR inhibitor (such as a limus drug, such as sirolimus or a derivative thereof) and an albumin, b) an effective amount of anti-VEGF antibody(such as bevacizumab), and c) a therapeutically effective FOLFOX regimen (such as FOLFOX4 or a modified FOLFOX6).

Description

[0001] Cross references to related applications [0002] This application claims priority to US Provisional Application No. 62 / 607,798 filed on December 19, 2017, the entire disclosure of which is incorporated herein by reference. Technical field [0003] The present invention relates to methods and compositions for the treatment of colon cancer-by including a composition comprising nanoparticles of mTOR inhibitors (such as limus drugs, such as sirolimus or its derivatives) and albumin, combined Anti-VEGF antibody and FOLFOX regimen. Background technique [0004] Colon cancer (colorectal cancer, CRC) has become a major health problem worldwide due to its high prevalence and high mortality. It is the third most common malignancy in developed countries and the second most common cause of cancer-related deaths. Although the progress of CRC treatment has had a significant impact on its management, many patients with advanced disease will eventually die from their cancer. [0005] The m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/282A61K31/519A61K31/513A61K39/395A61K31/436A61P35/00
CPCA61K39/3955A61K47/42A61P35/00A61K31/436A61K31/519A61K31/513A61K31/555A61K2300/00A61K45/06A61K47/643A61K39/395C07K2317/24C07K2317/76A61K9/5169C07K16/22B82Y5/00A61K9/0019A61K47/6929A61K47/6907A61K47/6925A61P35/02A61K2039/54A61K2039/545
Inventor N·P·德赛
Owner ABRAXIS BIOSCI LLC
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