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Method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and kit

A fingerprint, colorectal cancer technology, applied in the field of malignant tumor detection, can solve problems such as the prediction and evaluation of the efficacy of chemotherapy drugs, and achieve the effect of saving medical costs

Inactive Publication Date: 2013-09-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these studies still tend to monitor efficacy and assess prognosis, and do not directly predict and evaluate the efficacy of chemotherapy drugs

Method used

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  • Method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and kit
  • Method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and kit
  • Method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and kit

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Experimental program
Comparison scheme
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Embodiment

[0025] figure 1 Shown is the step flow diagram of the present invention, the first step is to set up the serum protein fingerprint spectrum standard model of FOLFOX and FOLFIRI chemotherapy method, specifically as follows:

[0026] (1) Source of specimen

[0027] From August 2008 to July 2010, a total of 70 patients with metastatic colorectal cancer who were pathologically diagnosed in Zhejiang Second Hospital (The Second Affiliated Hospital of Zhejiang University School of Medicine) had unresectable primary lesions, recurrence or Measurable lesions of metastases. All patients were treatment-naïve patients or those who had not received chemotherapy and other anticancer drugs in the last 6 months. Among them, there were 37 males and 33 females, aged 42-74 years, with a median age of 60 years; 44 cases of colon cancer, 26 cases of rectal cancer, high, medium and low (including mucinous adenocarcinoma and signet ring cell carcinoma) differentiated adenocarcinoma 16, 30, and 2...

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Abstract

The invention discloses a method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and a kit. The steps comprises: (1) respectively establishing serum protein fingerprinting for patient samples with advanced colorectal cancer, who suffer from a chemotherapy regimen; (2) extracting serum protein fingerprint characteristics in the serum protein fingerprinting of the obtained samples, and respectively establishing standard models based on the chemotherapy regimen; (3) establishing serum protein fingerprinting for patients with advanced colorectal cancer, who do not suffer from the chemotherapy regimen, and extracting the serum protein fingerprint characteristics; and (4) contrasting and analyzing the serum protein fingerprint characteristics of the patients who do not suffer from the chemotherapy regimen, with the standard models established in the step (2). The chemotherapy regimen may be FOLFOX or FOLFIRI. The method overcomes a blindness problem of a therapeutic regimen for advanced colorectal cancer. Before chemotherapy, the serum protein fingerprinting of the patients with advanced colorectal cancer is detected, to analyze the patient is a beneficiary of the FOLFOX regimen or the FOLFIRI regimen.

Description

technical field [0001] The invention belongs to the field of malignant tumor detection, and in particular relates to a method for modeling and analyzing late stage protein fingerprints of colorectal cancer and a kit. Background technique [0002] Colorectal cancer is one of the most common tumors in the world today, and its tumor-related mortality ranks third among malignant tumors. Most of the patients are already in the middle and advanced stages when they are diagnosed, and they lose the chance of surgery, and the main treatment is chemotherapy. The treatment of colorectal cancer has changed dramatically due to the emergence of new chemotherapy drugs, including: fluorouracil 5-FU, calcium folinate CF, irinotecan, oxaliplatin, these drugs are the treatment Classic drugs in colorectal cancer. Among these drugs, the two-drug combination chemotherapy regimen can improve the response rate and progression-free survival (PFS) compared with the 5-FU single-drug regimen, and can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
Inventor 沈虹潘平李颂元孟静磊袁明敏袁瑛黄建徐栋张苏展陈天洲
Owner ZHEJIANG UNIV
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