Method and kit for determining effectiveness of targeted drug apatinib

Abstract

The invention discloses a method and a kit for determining effectiveness of a targeted drug apatinib. The method comprises the following steps: step 1, preparing a drug effect sample of the targeted drug apatinib; 2, carrying out DNA molecular marking on the drug effect sample obtained in the step 1; 3, establishing a multiple linear regression mathematical model; 4, calculating the correlation coefficient of the effective variable of the drug effect of the targeted drug apatinib; and step 5, determining the effectiveness of the targeted drug apatinib according to the correlation coefficient of the effective variable of the drug effect. According to the method and the kit for determining the effectiveness of the targeted drug apatinib, provided by the invention, the efficacy effectivenessof the targeted drug apatinib is researched from a gene level in a DNA molecular marking manner, so that the efficacy degree of a drug scheme is associated with the expression of a gene, and the efficacy effectiveness of the targeted drug apatinib can be better determined; and predicting or assisting in predicting of the risk of the efficacy of the chemotherapy FOLFOX regimen is carried out.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method and a kit for detecting the effectiveness of a targeted drug apatinib during tumor treatment. Background technique [0002] Apatinib is the world's first small molecule anti-angiogenic targeted drug that has been proven safe and effective in advanced gastric cancer. It is also a single drug that significantly prolongs survival after the failure of standard chemotherapy for advanced gastric cancer. obvious. It is commonly used in advanced gastric cancer and advanced non-small cell lung cancer. A large number of clinical studies have shown that by inhibiting the formation of new blood vessels in tumor tissue, apatinib can significantly prolong the survival of patients with advanced gastric cancer. It also has certain curative effect on soft tissue sarcoma, liver cancer, triple negative, breast cancer and colorectal cancer. [0003] However, as a single drug for t...

AI Technical Summary

Problems solved by technology

DNA molecular markers are genetic markers based on nucleotide sequence variation in genetic material between individuals. They detect differences between organisms directly on DNA molecules and are a direct response to DNA level variation. DNA molecular markers are not affected by environmental gene expression or not. However, due to the large number of DNA molecular markers, it is difficult to screen out DNA molecular markers related to research purposes

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