Method and kit for determining effectiveness of targeted drug apatinib

An apatinib and effective technology, which is applied in the field of detection methods and kits for the effectiveness of targeted drug apatinib, can solve the problems of difficulty in screening DNA molecular markers, excessive number of DNA molecular markers, etc.

Pending Publication Date: 2021-01-29
南京普恩瑞生物科技有限公司
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

DNA molecular markers are genetic markers based on nucleotide sequence variation in genetic material between individuals. They detect differences between organisms directly on DNA molecules and are a direct response to DNA level v

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  • Method and kit for determining effectiveness of targeted drug apatinib
  • Method and kit for determining effectiveness of targeted drug apatinib
  • Method and kit for determining effectiveness of targeted drug apatinib

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Embodiment Construction

[0037] In order to make the purpose and technical solutions of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are some, but not all, embodiments of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

[0038] It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It should also be understood that terms such as those defined in general dictionaries should be...

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Abstract

The invention discloses a method and a kit for determining effectiveness of a targeted drug apatinib. The method comprises the following steps: step 1, preparing a drug effect sample of the targeted drug apatinib; 2, carrying out DNA molecular marking on the drug effect sample obtained in the step 1; 3, establishing a multiple linear regression mathematical model; 4, calculating the correlation coefficient of the effective variable of the drug effect of the targeted drug apatinib; and step 5, determining the effectiveness of the targeted drug apatinib according to the correlation coefficient of the effective variable of the drug effect. According to the method and the kit for determining the effectiveness of the targeted drug apatinib, provided by the invention, the efficacy effectivenessof the targeted drug apatinib is researched from a gene level in a DNA molecular marking manner, so that the efficacy degree of a drug scheme is associated with the expression of a gene, and the efficacy effectiveness of the targeted drug apatinib can be better determined; and predicting or assisting in predicting of the risk of the efficacy of the chemotherapy FOLFOX regimen is carried out.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method and a kit for detecting the effectiveness of a targeted drug apatinib during tumor treatment. Background technique [0002] Apatinib is the world's first small molecule anti-angiogenic targeted drug that has been proven safe and effective in advanced gastric cancer. It is also a single drug that significantly prolongs survival after the failure of standard chemotherapy for advanced gastric cancer. obvious. It is commonly used in advanced gastric cancer and advanced non-small cell lung cancer. A large number of clinical studies have shown that by inhibiting the formation of new blood vessels in tumor tissue, apatinib can significantly prolong the survival of patients with advanced gastric cancer. It also has certain curative effect on soft tissue sarcoma, liver cancer, triple negative, breast cancer and colorectal cancer. [0003] However, as a single drug for t...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G16B20/30G16B30/00G16B5/00
CPCC12Q1/6886G16B20/30G16B30/00G16B5/00C12Q2600/106C12Q2600/156
Inventor 郑晖谢剑邦朱燕萍
Owner 南京普恩瑞生物科技有限公司
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