Anionic chelate compounds

A compound, anion technology, used in the field of chelate compounds and their use as contrast agents in magnetic resonance procedures to improve safety characteristics and change the distribution of clearance rates

Active Publication Date: 2020-09-25
GENERAL ELECTRIC CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is still room for improvement of Mn(II) chelates

Method used

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  • Anionic chelate compounds
  • Anionic chelate compounds
  • Anionic chelate compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Example 1 describes a method for the synthesis of the exemplary compound Mn chelate 1 of the invention.

Embodiment 2

[0125] Example 2 describes a method for the synthesis of the prior art compound Mn platform.

Embodiment 3

[0126] Example 3 describes a method for measuring the rl and r2 relaxation rates of several Mn chelate compounds.

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Abstract

The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.

Description

technical field [0001] The present invention relates to chelate compounds and their use as contrast agents in magnetic resonance procedures. Background technique [0002] Magnetic resonance imaging (MRI) is a medical imaging technique in which regions of the body can be visualized via the nuclei of selected atoms, especially hydrogen nuclei. The MRI signal depends on the environment surrounding the visualized nucleus and its longitudinal and transverse relaxation times, termed T1 and T2, respectively. Thus, where the visualized nuclei are protons, the MRI signal intensity will depend on factors such as proton density and the chemical environment of the protons. [0003] Contrast agents that include paramagnetic metal ions in their chemical structure can be used in MRI to improve imaging contrast. They work by affecting the relaxation time and thus the contrast in the image. Contrast agents comprising the paramagnetic metal ion Gd(III) are well known and include the commer...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): C07B59/00C07D471/08A61K51/00
CPCC07B59/004C07D471/08A61K49/106C07F13/00C07F13/005
InventorB·C·巴勒斯M·J·利修埃尔
OwnerGENERAL ELECTRIC CO