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An improved thermal modulator

A technology of modulators and supporting elements, which can be used in instruments, scientific instruments, measuring devices, etc., to solve problems such as difficult temperature detection and evaluation, and difficulty in determining and modifying the temperature of analyte release.

Pending Publication Date: 2020-10-23
珀金埃尔默科学意大利股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0026] ﹣The temperature at which the analyte is released is not easily determined and modified,
[0027] – The temperature actually reached by the convective gas (and capillary) during both the cooling and heating phases is difficult to detect and evaluate

Method used

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Examples

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Embodiment Construction

[0053] As can be seen from the figure, the modulator 2 according to the invention comprises an analytical capillary 4 intended to be connected between two gas chromatographic columns 1, 3, preferably with different Separation properties.

[0054] Conveniently, the analytical capillary 4 may be physically constituted by a separate section of the chromatographic column relative to the two chromatographic columns 1 and 3, or alternatively it may be formed by the end portion of the first chromatographic column 1 or by the second chromatographic column 3's initial segment composition.

[0055] Suitably, the analytical capillary 4 is made of metal, preferably a nickel alloy (eg Inconel 600, Inconel 625 or others) or steel (eg SS316 and others).

[0056] Advantageously, the inner wall of the analytical capillary 4 is suitably inert from a chemical point of view. Advantageously, the internal diameter of the analytical capillary 4 is approximately 50 μm-250 μm, preferably 100 μm.

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PUM

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Abstract

Improved thermal modulator (2) for gas chromatography comprising: an analytical capillary (4) to be passed through by analytes and intended to be interposed between two gas chromatographic columns (1,3), a cooling system (8) comprising a cold zone (10), a support element (11) associated with said cold zone (10) and configured to support a portion (17) of said analytical capillary (4) so that saidportion (17) is at a substantially corresponding or slightly higher temperature, with respect to that of said cold zone (10), said portion (17) of said analytical capillary (4) which passes through and / or is in contact with said support element (11) thus defining the trapping portion (17) in which the analytes passing through said capillary (4) are intended to be trapped / immobilized, control means (14) which selectively control the sending of pulsed current to electrically conductive elements (70, 71) associated with said analytical capillary (4) so as to heat said trapping portion (17), thuscausing the release / desorption of previously immobilized analytes, means (80) to cause the heating of a portion (81) of said analytical capillary (4) which is positioned outside of said support element (11) and upstream of said portion (17) of said capillary tube which passes through and / or is in contact with said support element (11) so as to generate a rapid expansion of the gas, which is contained in said portion (81), along the direction of development of said analytical capillary (4), thus facilitating the advancement of the analytes released / desorbed towards the outlet of said portion (17).

Description

technical field [0001] The present invention relates to an improved thermal modulator for use in gas chromatography. Background technique [0002] Modulators are known for maximizing the efficiency of the separation process in conventional gas chromatography and in two-dimensional gas chromatography or GC x GC (integrated GC x GC), which are used to regroup sample bands , a two-dimensional gas chromatograph, or GC×GC, is used to prevent the distillate from leaving the first column and subsequently separate the distillate into small fractions that enter at regular intervals in the second column, so The second chromatographic column typically, but not exclusively, has different separation properties than the first chromatographic column. [0003] Gas chromatography is widely used in separation and analysis techniques in various fields, such as environmental fields, petrochemical fields, pharmaceutical fields, and even one of flavors and fragrances. [0004] Traditionally, a ...

Claims

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Application Information

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IPC IPC(8): G01N30/46
CPCG01N30/463G01N30/465G01N30/12G01N2030/121G01N30/30G01N2030/025G01N2030/3053
Inventor W·W·卡森A·克罗蒂M·塞尼R·塔什尼
Owner 珀金埃尔默科学意大利股份有限公司
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