Application of tweak in the preparation of diagnostic reagents for lupus erythematosus

A lupus erythematosus and diagnostic reagent technology, applied in the field of biomedicine, can solve the problems of increasing the cost of patient testing and insufficient prediction of lupus nephritis damage.

Active Publication Date: 2022-03-08
XI AN JIAOTONG UNIV
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Problems solved by technology

[0004] However, most of the current indicators need to be combined with clinical manifestations when evaluating disease activity, or require multiple laboratory results, which may take a long time and increase the cost of testing for patients
In addition, the lupus erythematosus scoring system and individual organ / system assessment scales may not be sufficient to predict damage to vital organs such as lupus nephritis (LN), which may also be affected by systemic inflammation

Method used

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  • Application of tweak in the preparation of diagnostic reagents for lupus erythematosus
  • Application of tweak in the preparation of diagnostic reagents for lupus erythematosus
  • Application of tweak in the preparation of diagnostic reagents for lupus erythematosus

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Embodiment Construction

[0025] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0026] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses the application of TWEAK in the preparation of lupus erythematosus diagnostic reagents, and belongs to the technical field of biomedicine. The present invention studies the role of serum and urine TWEAK levels in the diagnosis of different types of lupus erythematosus, and evaluates the relationship between TWEAK and SLE disease activity index (SLEDAI), so as to clarify its role in the process of disease diagnosis and monitoring, and in the The guiding role of glucocorticoid dosage, reduction and disease outcome in SLE treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of TWEAK in the preparation of lupus erythematosus diagnostic reagents. Background technique [0002] Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a pro-inflammatory factor mainly synthesized by macrophages and monocytes. By binding to its receptor fibroblast growth factor-inducible14 (Fn14), it induces the production of downstream cytokines, such as interferon-γ-induced protein 10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), and regulation of normal T cell expression and secretion of chemokines (RANTES) and other pathways involved in the pathogenesis of lupus erythematosus. [0003] Systemic lupus erythematosus (SLE) is a severe autoimmune disease involving multiple systems and organs. Systemic application of glucocorticoids is currently the main treatment for SLE patients. However, in most patients the condition recurs during the c...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/564G01N33/58G01N33/543
CPCG01N33/564G01N33/581G01N33/54393G01N2800/104G01N2333/70575
Inventor 夏育民陈静云王绘霞陈文文王晓宇罗迈刘玮
Owner XI AN JIAOTONG UNIV
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