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Microscopic imaging component, device, system and imaging method using array objective lens

A microscopic imaging and imaging method technology, applied in microscopes, optical components, instruments, etc., can solve the problems of limited observation area size and poor timeliness of observation of microscopic systems

Active Publication Date: 2021-11-16
XI'AN INST OF OPTICS & FINE MECHANICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to solve the technical problems of poor observation timeliness and limited observation area size in existing microscopic systems, and to provide a microscopic imaging component, device, system and imaging method using an array objective lens

Method used

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  • Microscopic imaging component, device, system and imaging method using array objective lens
  • Microscopic imaging component, device, system and imaging method using array objective lens
  • Microscopic imaging component, device, system and imaging method using array objective lens

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Embodiment 1

[0059] A microscopic imaging system using an arrayed objective lens, such as Figures 1 to 3 As shown, it includes an objective lens array 2 (array imaging objective lens), a field lens combination 3 (double field lens assembly), a secondary compensation magnification lens group 4 (near field image transmission mirror) and a detector arranged in sequence along the light transmission direction 6 (electronics focal plane detector, image sensor, commercial detector of 5-10 micron pixel resolving power); Described objective lens array 2 comprises 3 * 3 objective lens units 201 (that is 9 Near-field low-magnification objective lens units 201 with consistent parameters are arranged in a nine-square grid); each objective lens unit 201 includes a first objective lens 2011 and a primary magnification lens group 2012 arranged in sequence along the light transmission direction; the field lens combination 3 includes In the transmission direction, a first field lens array 301 and a second ...

Embodiment 2

[0074] The difference with embodiment 1 only lies in:

[0075] In step 2) of the imaging method, the control of the translation of the sample slide in the object plane 1 by the two-dimensional translation stage is replaced by the control of the imaging system to perform three translations in the plane perpendicular to the optical axis.

Embodiment 3

[0077] The difference with embodiment 1 only lies in:

[0078] Such as Figure 6 As shown, one detector 6 at the image plane 5 of the imaging system is replaced with 3×3 detectors 6 arranged coplanarly in an array and corresponding to 3×3 objective lens units 201 one-to-one. In imaging, Each detector can effectively overcome the image plane curvature (field curvature) effect caused by the large field of view hybrid optical axis imaging system through small adjustments of tilt and working distance, and further obtain high-resolution imaging results.

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Abstract

The invention relates to a microscopic imaging component, device, system and imaging method for realizing staring imaging with a large field of view by using an array objective lens. The purpose of the invention is to solve the technical problems of poor observation timeliness and limited observation area size existing in the existing microscopic system. The present invention replaces a single objective lens with an objective lens array on the basis of the existing compound microscope system with a primary phase surface and imaging by a computer, and adds a field lens combination between the objective lens array and the secondary compensation magnification lens group, through The field lens combination respectively flattens the objective lens array and the secondary compensation magnification lens group, and realizes the transformation of multiple optical axes to a single optical axis. During imaging, the sample slide and the microscopic system perform a limited number of relative translations, so that in During the test, the objective lens array can completely cover the entire field of view of the sample slide, exposure imaging is performed at the initial position and after each translation, and the images obtained by multiple imaging are fused to obtain a global image of the sample target area.

Description

technical field [0001] The invention relates to a microscopic imaging device, in particular to a microscopic imaging component, device, system and imaging method for realizing staring imaging with a large field of view by using an arrayed objective lens. Background technique [0002] It has been more than 400 years since humans first used optical lenses in the true sense to magnify objects (1590, originated in the Netherlands), and the first recognized microscope appeared at the end of the 17th century. As an indispensable optical instrument for human beings in many disciplines such as biology, chemistry, medicine and physics, microscopes continue to play an important role in scientific research and production. [0003] Divided from the form of composition, microscopes can be divided into single-lens systems, tube-lens microscope systems and compound microscope systems. [0004] The representative of the single-lens system is the Hooke microscope, which has a simple structu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G02B21/02
CPCG02B21/02
Inventor 孙鑫白永林李然陈震石大莲王乐
Owner XI'AN INST OF OPTICS & FINE MECHANICS - CHINESE ACAD OF SCI