A composition with anti-inflammatory synergistic effect and application thereof
A technology of synergistic effect and composition, applied in the field of drug research, can solve the problems of anti-inflammatory synergistic effect of flavonoids, etc., and achieve significant anti-inflammatory synergistic effect, reduce granuloma index, and reduce the content of histamine Effect
Active Publication Date: 2022-06-07
新疆维吾尔自治区中药民族药研究所
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Problems solved by technology
[0006] Although studies have confirmed that most flavonoids in licorice have certain anti-inflammatory effects, there is no research on whether the flavonoids have anti-inflammatory synergistic effects and how to combine various flavonoids to improve the anti-inflammatory synergistic effect
Most of the existing literature reports are about the anti-inflammatory activity of total licorice flavonoids or a single licorice flavonoid compound, but there are few reports on the combined application of licorice flavonoid compounds
Method used
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Embodiment 1
[0019] Example 1: Composition with anti-inflammatory synergistic effect
[0020] The composition is composed of licorice chalcone A and licorice flavonoid B, and the two are prepared in a molar ratio of 50:50.
Embodiment 2
[0021] Example 2: Composition with anti-inflammatory synergistic effect
[0022] The composition is composed of licorice chalcone A and licorice flavonoid B, and the two are prepared in a molar ratio of 60:40.
Embodiment 3
[0023] Example 3: Composition with anti-inflammatory synergistic effect
[0024] The composition is composed of licorice chalcone A and licorice flavonoid B, which are prepared in a molar ratio of 56:44.
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The invention discloses a composition with anti-inflammatory synergistic effect, which is composed of licochalcone A and licorice flavonoid B, and the two are in the molar ratio (1-7):(1-3) preparation. Compared with licochalcone A or licorice flavonoid B, the anti-inflammatory activity of the composition provided by the invention is significantly enhanced, and it is superior to other flavonoid compounds and compositions, indicating that there is an obvious anti-inflammatory synergistic effect between the two . It has been confirmed by different inflammatory models that when licorice chalcone A and licorice flavonoid B are combined, the anti-inflammatory synergistic effect is prominent, and it is licorice flavonoid B that significantly affects the anti-inflammatory activity of licorice chalcone A or other compositions, overcoming the existing There is a technical prejudice that the content of licochalcone A is higher or significantly higher than that of licorice flavonoid B to have significant anti-inflammatory activity. In particular, when the combination ratio of licochalcone A and licorice flavonoid B is 1:1, the anti-inflammatory activity of the composition is the highest, and has wide application value in the field of anti-inflammatory.
Description
technical field [0001] The invention belongs to the field of drug research, and mainly relates to a composition with an anti-inflammatory synergistic effect and the technical field of its application. [0002] technical background [0003] Flavonoids generally have anti-inflammatory activities, but their anti-inflammatory activities are closely related to their chemical structures. For example, sugar groups can significantly affect the anti-inflammatory activity of flavonoid carbon glycosides, and their contribution to anti-inflammatory activity is much greater than that of phenolic hydroxyl groups; as the number of sugar groups increases, the anti-inflammatory activity of the compounds also increases, and sugar substituents The smaller the group polarity, the smaller the anti-inflammatory activity of the compound; and the anti-inflammatory activity of flavonoid carbon glycosides is stronger than that of flavonoid oxygen glycosides, which further proves the influence of sugar...
Claims
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IPC IPC(8): A61K31/352A61P29/00A61K31/12
CPCA61K31/12A61K31/352A61P29/00A61K2300/00Y02A50/30
Inventor 张娟卿德刚孙宇徐晓琴斯建勇何帅兵王钧篪者炜
Owner 新疆维吾尔自治区中药民族药研究所
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