Application of persimmon leaf extract in treatment of insomnia

A technology of persimmon leaf extract and sleep, applied in the field of medicine, can solve problems such as complex composition of active substances, complex causes of insomnia, and unclear mechanism of treatment of insomnia

Pending Publication Date: 2022-02-01
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the complex causes of insomnia and the unclear mechanism of insomnia treatment, it has always been a difficult problem to improve sleep safely and effectively. In addition, the composition of the active substances in the extract is complex. For the persimmon leaf extract prepared by modern separation technology, the active substances in the persimmon leaf Or whether the extract can be effective for insomnia or what kind of insomnia is effective, as well as its safety, it is not clear at present

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of persimmon leaf extract in treatment of insomnia
  • Application of persimmon leaf extract in treatment of insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Effect of persimmon leaf extract of the present invention on mice falling asleep caused by sodium pentobarbital 1. Experimental animals

[0047] 60 healthy Kunming mice, clean grade, half male and half female, weighing 18-22 g. Experimental animal license number: SCXK (Beijing) 2014-0004; the mice were adapted to the feeding environment for one week before the experiment, and all mice were kept in a normal-grade experimental animal room with a temperature of 21±2°C and followed the circadian rhythm. Mice had free access to food and water.

[0048] 2. Experimental Drugs

[0049] Both persimmon leaf extract (NXQ) and alprazolam were prepared using 0.5% sodium carboxymethylcellulose as a solvent, and the drugs should be fully vortexed before administration.

[0050] Preparation of Persimmon Leaf Extract (NXQ): Dissolve 40mg of Persimmon Leaf Extract in 10ml of 0.5% Sodium Carboxymethyl Cellulose to prepare a 4mg / ml stock solution. liquid. For example, if the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of a persimmon leaf extract in preparation of a medicine for treating primary insomnia, in particular to insomnia with difficulty in falling asleep. Each dose group of the persimmon leaf extract can increase the number of mice falling asleep caused by subthreshold dose pentobarbital sodium in a dose-dependent manner, and can also shorten the sleep latency caused by suprathreshold dose pentobarbital and prolong the sleep duration caused by suprathreshold dose pentobarbital in a dose-dependent manner. The persimmon leaf extract is used for treating primary insomnia, and is low in effective dose and good in patient compliance and safety.

Description

[0001] The present invention is a divisional application with application number: CN201711334516.X, application date: 2017-12-12, and the title of the invention is "Application of persimmon leaf extract in the treatment of insomnia". technical field [0002] The invention belongs to the field of medicine, and in particular relates to a new medical application of persimmon leaf extract. Background technique [0003] Insomnia is one of the manifestations of sleep disorders. It usually refers to the occurrence and (or) maintenance of sleep disorders leading to sleep loss. It is manifested as difficulty in falling asleep, easy to wake up, early awakening and difficulty in falling asleep again. Physiological demands, resulting in daytime lethargy, lethargy, and a range of neuropsychiatric symptoms. [0004] Modern medicine classifies insomnia according to the course of the disease: transient insomnia (less than 1 week), short-term insomnia (1 week to 1 month) and chronic insomnia...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/44A61P25/20A61K127/00
CPCA61K36/44A61K2236/39A61K2236/53A61K2236/331A61P25/20A61K2236/51
Inventor郭海彪李淑如李楚源王德勤
OwnerGUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE