Application of persimmon leaf extract to treatment of insomnia

A persimmon leaf extract and medicine technology, applied in the field of medicine, can solve the problems of lack of guidance on clinical precision medicine, undisclosed insomnia symptom evaluation standard and specific types of improvement result indicators, etc.

Inactive Publication Date: 2018-05-11
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The study did not disclose the specific evaluation criteria for insomnia symptoms, the indicators of insomnia improvement results, or the specific types of insomnia, which lacks guidance for clinical precision medicine

Method used

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  • Application of persimmon leaf extract to treatment of insomnia
  • Application of persimmon leaf extract to treatment of insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Effect of persimmon leaf extract of the present invention on mice falling asleep caused by sodium pentobarbital

[0042] 1. Experimental animals

[0043] 60 healthy Kunming mice, clean grade, half male and half female, weighing 18-22 g. Experimental animal license number: SCXK (Beijing) 2014-0004; the mice were adapted to the feeding environment for one week before the experiment, and all mice were kept in a normal-grade experimental animal room with a temperature of 21±2°C and followed the circadian rhythm. Mice had free access to food and water.

[0044] 2. Experimental Drugs

[0045] Both persimmon leaf extract (NXQ) and alprazolam were prepared using 0.5% sodium carboxymethylcellulose as a solvent, and the drugs should be fully vortexed before administration.

[0046] Preparation of Persimmon Leaf Extract (NXQ): Dissolve 40mg of Persimmon Leaf Extract in 10ml of 0.5% Sodium Carboxymethyl Cellulose to prepare a 4mg / ml stock solution. liquid. For examp...

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Abstract

The invention relates to an application of persimmon leaf extract to preparation of drugs for treating primary insomnia, especially for treating sleep onset insomnia. For all dose groups of the persimmon leaf extract, the quantity of mice falling asleep by subthreshold dose of pentobarbital sodium can be increased dose-dependently, sleep latency by suprathreshold dose of pentobarbital sodium can be shortened dose-dependently, and sleep time by suprathreshold dose of pentobarbital sodium can be prolonged dose-dependently. When used for treating primary insomnia, the persimmon leaf extract has the advantages that the effecting dose is low, and compliance and safety of patients are good.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new medical application of persimmon leaf extract. Background technique [0002] Insomnia is one of the manifestations of sleep disorders. It usually refers to the occurrence and (or) maintenance of sleep disorders leading to sleep loss. It is manifested as difficulty in falling asleep, easy to wake up, early awakening and difficulty in falling asleep again. Physiological demands, resulting in daytime lethargy, lethargy, and a range of neuropsychiatric symptoms. [0003] Modern medicine classifies insomnia according to the course of the disease: transient insomnia (less than 1 week), short-term insomnia (1 week to 1 month) and chronic insomnia (more than 1 month). According to the etiology, it is divided into primary insomnia and secondary insomnia: ①Primary insomnia: According to the diagnostic criteria of primary insomnia in the American Diagnostic and Statistical Manual ...

Claims

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Application Information

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IPC IPC(8): A61K36/44A61P25/20A61K127/00
CPCA61K36/44A61K2236/39A61K2236/53A61K2236/331A61P25/20A61K2236/51
Inventor郭海彪李楚源王德勤李淑如
OwnerGUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE