Traditional Chinese medicine for treating circadian rhythm disorder sleep disorder and preparation method thereof

A technology for circadian rhythm disorders and sleep disorders, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and medical raw materials derived from mollusks, etc. Theory, ignoring the treatment methods of long-term recuperation, etc., to achieve the effect of shortening the time to fall asleep, promoting the restoration of balance between excitation and inhibition, and prolonging the duration of sleep

Active Publication Date: 2021-10-26
陕西省中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In summary, TCM has a mature theoretical basis for treating insomnia from the perspective of the liver, but overall, there are still some problems: (1) TCM has rich clinical experience in treating insomnia, and TCM research has not fully reflected (2) Clinically, doctors are only one-sidedly pursuing the effect of "sedation and tranquilization" in treating patients, while ignoring the existing human body's circadian function and psychological disorder, so they cannot improve the patient's sleep quality. Fatigue during the day and night; (3) Most patients and doctors pay attention to simple and fast treatment methods during treatment, while ignoring long-term treatment methods

Method used

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  • Traditional Chinese medicine for treating circadian rhythm disorder sleep disorder and preparation method thereof
  • Traditional Chinese medicine for treating circadian rhythm disorder sleep disorder and preparation method thereof
  • Traditional Chinese medicine for treating circadian rhythm disorder sleep disorder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0230] For the treatment of circadian rhythm disorder sleep disorders, the raw material composition and weight of the active ingredients of the traditional Chinese medicine are: paeonol 107.2g, Gardenia 107.2g, Scutellaria baicalensis 107.2g, Bupleurum 107.2g, mica stone 101.2g g, Curcuma 107.2g, Poria cocos 214.4g, white peony root 160.8g, bergamot root 113.5g, Atractylodes macrocephala 160.8g, fried jujube kernel 321.6g, pig gallbladder eggplant 156.3g, Baiziren 321.6g, melon peel 134.8g, polygala 107.2g, 160.8g Chuanxiong, 107.2g angelica, 106.8g dried earthworm, 321.6g keel, 321.6g oyster, 117.4g sandalwood mud, 214.4g silk bark, 107.2g nard pine.

[0231] The preparation method of the above-mentioned traditional Chinese medicine medicament for treating circadian rhythm disorder sleep disorder comprises the following steps:

[0232] (1) Cortex paeonol, gardenia, scutellaria baicalensis, Bupleurum, mica stone, turmeric, poria cocos, white peony root, bergamot root, Atractyl...

Embodiment 2

[0237] The traditional Chinese medicine medicament for the treatment of circadian rhythm disorder sleep disorder, the raw material composition and the weight of the active ingredients of the said traditional Chinese medicine medicament are Danpi 102g, Gardenia 102g, Scutellaria baicalensis 102g, Bupleurum 102g, mica stone 95g, Curcuma 102g, Poria cocos 205g, white peony root 155g, bergamot root 110g, Atractylodes macrocephala 155g, fried jujube kernel 310g, porcini eggplant 150g, baiziren 317g, melon skin 130g, polygala 102g, chuanxiong 155g, angelica 102g, dried earthworm 105g, keel 310g, 310g oysters, 115g sandalwood mud, 205g acacia skin, 102g nard pine

[0238] The preparation method of the above-mentioned traditional Chinese medicine medicament for treating circadian rhythm disorder sleep disorder comprises the following steps:

[0239] (1) Cortex paeonol, gardenia, scutellaria baicalensis, Bupleurum, mica stone, turmeric, poria cocos, white peony root, bergamot root, Atr...

Embodiment 3

[0245] The traditional Chinese medicine medicament for treating circadian rhythm disorder sleep disorder, the raw material composition and the weight of the active ingredients of the said traditional Chinese medicine medicament are Danpi 112g, Gardenia 112g, Scutellaria baicalensis 112g, Bupleuri 112g, mica stone 110g, Curcuma 112g, Poria cocos 223g, white peony root 165g, bergamot root 117g, Atractylodes macrocephala 165g, fried jujube kernel 330g, porcini eggplant 165g, baiziren 324g, melon skin 140g, polygala 112g, chuanxiong 165g, angelica 112g, dried earthworm 109g, keel 330g, 330g oysters, 120g sandalwood mud, 223g acacia skin, 112g nard pine

[0246] The preparation method of the above-mentioned traditional Chinese medicine medicament for treating circadian rhythm disorder sleep disorder comprises the following steps:

[0247] (1) Cortex paeonol, gardenia, scutellaria baicalensis, Bupleurum, turmeric, Poria cocos, white peony root, Atractylodes macrocephala, fried jujube ...

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Abstract

The invention discloses a traditional Chinese medicinal agent for treating circadian rhythm disorder sleep disorder. The active ingredients contained in the traditional Chinese medicinal medicinal agent include paeonol, gardenia, scutellaria baicalensis, Bupleuri, mica stone, turmeric, poria cocos, white peony root and bergamot Tangerine root, Atractylodes macrocephala, fried jujube kernel, pig gallbladder eggplant, baiziren, melon wilt skin, polygala, chuanxiong, angelica, dried earthworm, keel, oyster, sandalwood mud, acacia skin, nard pine, and also discloses a preparation The method of the above-mentioned traditional Chinese medicine, the above 23 traditional Chinese medicines, add water to decoct twice, each time add 10 times the amount of water, decoct for 1.5 hours, combine the decoction, stand for 12 hours, filter, and the filtrate is concentrated to a relative density of 1.30-1.45 For the clear paste, mix the clear paste and dextrin at a mass ratio of 1:1, dry at 80°C, grind it into an 80-mesh sieve to prepare a fine powder, add 0.04 times of stevioside and mix well, add 75% ethanol to the right amount Used as a wetting agent to granulate and granulate. The invention adopts the traditional Chinese medicine to treat the circadian rhythm disorder sleep disorder, and has the advantages of good curative effect, light side effect, good compliance and no dependence.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine medicine for treating circadian rhythm disorder sleep disorder and a preparation method thereof. Background technique [0002] The circadian rhythm is a natural cycle established by organisms in nature to adapt to the external environment. All life activities in nature rely on the circadian rhythm. However, with the development of society and the gradual increase of social pressure, the survey found that due to job requirements, shift workers must change their daily schedules, and the light-dark cycle of the external environment changes relative to the individual circadian rhythm. If things go on like this, it will increase the rhythm disorder of shift workers Risk of developing sleep disorders. At present, melatonin and light therapy are the main means of regulating circadian rhythm, but the therapeuti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P25/20A61P25/00A61K35/62A61K35/02A61K35/618
CPCA61K33/06A61K35/02A61K35/618A61K35/62A61K36/076A61K36/14A61K36/185A61K36/232A61K36/233A61K36/236A61K36/284A61K36/428A61K36/48A61K36/539A61K36/65A61K36/69A61K36/71A61K36/725A61K36/744A61K36/752A61K36/81A61K36/84A61K36/9066A61K2236/331A61K2236/39A61P25/00A61P25/20A61K2300/00
Inventor 陈钧惠振亮乔树真吴鹏亮阮邵萍
Owner 陕西省中医医院
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