Nasal spray for treating apoplexy and preparation method thereof

A technology of nasal spray and musk, which is applied in the field of Chinese patent medicine, can solve the problems of unclear and difficult pathogenesis and treatment mechanism, and achieve the effects of avoiding the first-pass effect, fast drug absorption and strong effect

Inactive Publication Date: 2012-05-30
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, because there are many causes of stroke, and the pathogenesis and treatment mechanism are not yet very clear, although the current treatment of stroke has made progress, there are still great difficulties. Therefore, it is necessary to screen and optimize the prescription of traditional Chinese medicine commonly used in clinical practice. , developed a multi-link, multi-level, multi-target Chinese patent medicine

Method used

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  • Nasal spray for treating apoplexy and preparation method thereof
  • Nasal spray for treating apoplexy and preparation method thereof
  • Nasal spray for treating apoplexy and preparation method thereof

Examples

Experimental program
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Effect test

example 1

[0103] Prescription: Musk 3g, Shichangpu 40g, Borneol 5g, Pig Tooth Soap 30g.

[0104] Preparation method:

[0105] 1. Extract the active ingredients in musk, calamus and pig tooth soap respectively:

[0106] Extraction of musk: take musk and add 10 times the concentration of 60% ethanol for ultrasonic extraction 3 times, each time for 5 minutes, filter, combine the filtrate, evaporate the ethanol, and set aside; add 10 times water to extract musk residue 2 times, each time 1 hour, filtered, and the filtrate was concentrated to 50ml for later use.

[0107] Extraction of Shichangpu: Take Shichangpu and add 6 times the amount of water to distill for 6 hours, and collect the volatile oil for later use.

[0108] Extraction of pig tooth soap: Take pig tooth soap and add 6 times the amount of 60% ethanol to reflux and extract 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.15 (65°C) for...

example 2

[0112] Prescription: Musk 41g, Shichangpu 245g, Borneol 41g, Pig Tooth Soap 165g.

[0113] Preparation method:

[0114] 1. Extract the active ingredients in musk, calamus and pig tooth soap respectively:

[0115] Extraction of musk: take musk and add 6-10 times the amount of 60-95% ethanol to ultrasonically extract 3 times, each time for 5 minutes, filter, combine the filtrate, evaporate the ethanol, and set aside; add 6-10 times the amount of water to extract the musk residue 2 times, each time for 1 hour, filtered, and the filtrate was concentrated to 80ml for later use.

[0116] Extraction of Shichangpu: Take Shichangpu and add 6 times the amount of water to distill for 6 hours, and collect the volatile oil for later use.

[0117] Extraction of pig tooth soap: Take pig tooth soap and add 6 times the amount of 60% ethanol to reflux and extract 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative ...

example 3

[0121] Prescription: Musk 30g, Shichangpu 200g, Borneol 40g, Pig Tooth Soap 200g.

[0122] Preparation method:

[0123] 1. Extract the active ingredients in musk, calamus and pig tooth soap respectively:

[0124] Extraction of musk: take musk and add 8 times the concentration of 80% ethanol to ultrasonically extract 3 times, each time for 5 minutes, filter, combine the filtrate, evaporate the ethanol, and set aside; add 8 times water to the musk residue and extract 2 times, each time 1 hour, filtered, and the filtrate was concentrated to 70ml for later use.

[0125] Extraction of Shichangpu: Take Shichangpu and add 6 times the amount of water to distill for 6 hours, and collect the volatile oil for later use.

[0126] Extraction of pig tooth soap: take pig tooth soap and add 6 times concentration of 60% ethanol to reflux extraction for 3 times, each time for 2 hours, filter, combine filtrates, recover ethanol under reduced pressure and concentrate to a relative density of 1....

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Abstract

The invention relates to a Chinese patent medicine taking traditional Chinese medicines as raw materials, in particular to a nasal spray for treating apoplexy. The nasal spray is characterized in that: each liter of liquid medicine of the nasal spray is mainly prepared from the following raw material medicines in proportion by weight: 2-80g of musk, 40-450g of rhizoma acori graminei, 2-80g of borneol and 30-300g of fructus gleditsiae. In the invention, the nasal spray can be used for treating acute apoplexy, and has the advantages of high bioavailability, quick medicinal absorption, strong effect and convenience for use.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine using traditional Chinese medicine as a raw material. Background technique [0002] Stroke, also known as cerebral apoplexy, is a general term for acute cerebrovascular diseases in traditional Chinese medicine. It is a type of disease whose main symptoms are hemiplegia with sudden fainting, unconsciousness, crooked mouth and speech difficulties. Due to the high morbidity rate, high mortality rate, high disability rate, high recurrence rate and many complications of this disease, the medical community lists it as the three major diseases that threaten human health together with coronary heart disease and cancer. [0003] According to recent data, there are about 5 million stroke patients in my country, 2 million new cases each year, and 1 million deaths each year. Among the surviving patients, 75% have different degrees of loss of working ability, and more than 40...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K36/888A61P9/10A61K31/045A61K35/55
Inventor方永奇李翎柯雪红邹衍衍王淑英莫镇涛刘林
OwnerTHE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE