Application of CFTR enhancer in medicine for predicting and treating recurrent abortion

A technology of enhancer and drug, which is applied in the application of CFTR enhancer in the prediction and treatment of recurrent miscarriage, and the application field in the preparation of drugs for treating endometrial decidualization diseases, which can solve the problem of unclear pathogenesis and lack of pertinence. interventions and treatment options

Active Publication Date: 2022-02-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the unclear pathogenesis, there is currently a lack o...

Method used

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  • Application of CFTR enhancer in medicine for predicting and treating recurrent abortion
  • Application of CFTR enhancer in medicine for predicting and treating recurrent abortion
  • Application of CFTR enhancer in medicine for predicting and treating recurrent abortion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The concentration of intracellular chloride ion in endometrial stromal cells in secretory phase of women with a history of repeated miscarriage / repeated implantation failure is higher than that in normal women's endometrial cells in secretory phase; the expression of CFTR chloride channel gene mRNA and protein is higher than that in normal women's endometrium Stromal cells were low, and the degree of endometrial decidualization was worse than that of healthy controls.

[0057] (1) Materials and methods

[0058] 1. Endometrium sampling and grouping of clinical women:

[0059] After approval by the Ethics Committee of the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, the endometrium of the volunteer population was collected from the Sun Yat-sen Memorial Hospital of Sun Yat-sen University. According to the birth history of the volunteers, the test tissue samples were divided into women with repeated miscarriage / repeated implantation failure group (2 or more spo...

Embodiment 2

[0072] CFTR enhancer VX-770 can reduce the abnormally elevated chloride ion concentration in endometrial stromal cells of women with a history of recurrent miscarriage / repeated implantation failure, and attenuates the process of decidualization induced by MPA and 8-Br-cAMP in vitro recover.

[0073] (1) Materials and methods

[0074] 1. The endometrium of women with a history of repeated miscarriage / repeated implantation failure is obtained from the menstrual cycle:

[0075] After approval by the Ethics Committee of the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, the menstrual cycle endometrium of the volunteer population was collected from the Sun Yat-sen Memorial Hospital of Sun Yat-sen University. According to the reproductive history of the volunteers, the test tissue samples were divided into women with repeated miscarriage / repeated implantation failure group (women with 2 or more spontaneous abortions and repeated implantation failures of 5 or more high-qua...

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Abstract

The invention discloses a method for measuring intracellular chlorine concentration or chloride channel gene CFTR expression of human endometrial stromal cells in a menstrual cycle so as to predict prognosis of endometrial deciduation related diseases of the human endometrial stromal cells. Intracellular chlorine concentration up-regulation and chlorine channel gene CFTR expression down-regulation in endometrial stromal cells in a menstrual cycle can hinder deciduation of the endometrial cells, and finally, repeated abortion/repeated implantation failure is caused. Restoration of CFTR expression and/or reduction of chloride ion concentration in endometrial stromal cells in a menstrual cycle can improve uterine decidualization and improve the outcome of recurrent abortion/recurrent implantation failure. The invention develops a new field for clinical prediction and treatment of recurrent abortion/recurrent implantation failure, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of CFTR enhancers in recurrent miscarriage prediction and treatment drugs. The invention relates to a new application of a CFTR enhancer / corrector in the medical field. It specifically relates to the application of CFTR enhancer / corrector in the preparation of medicines for treating endometrial decidualization diseases. The endometrial decidualization-related diseases are diseases related to unexplained repeated abortion or repeated implantation failure. The endometrial decidualization-related diseases include increased intracellular chloride ion concentration in endometrial stromal cells, decreased expression of CFTR gene mRNA and / or protein, and endometrial decidualization disorders in menstrual cycle under pathological conditions. Background technique [0002] Chloride ion is the main anion inside and outside the cell, and its transmembrane transport part...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/47A61P15/06A61P15/00G01N21/64
CPCA61K45/00A61K31/47A61P15/06A61P15/00G01N21/6486
Inventor 王冠蕾张超李扬志
Owner SUN YAT SEN UNIV
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