Blood glucose signal acquisition device, and blood glucose concentration detection device and system

Abstract

The invention relates to the field of medicine, and concretely relates to a blood glucose signal acquisition device, and a blood glucose concentration detection device and system. The blood glucose signal acquisition device comprises a bottom plate, an SERS substrate, a pressure sensor and a Raman spectrometer, wherein the bottom plate is provided with a through hole part; the SERS substrate is mounted on the bottom plate, and at least partial area of the SERS substrate is arranged in the through hole part; the pressure sensor is arranged on the SERS substrate or the bottom plate and is used for detecting the pressure borne by the SERS substrate; and the Raman spectrometer is arranged below the SERS substrate. Compared with the prior art, the Raman spectrometer is used for collecting the blood glucose Raman signal through the SERS substrate, the pressure sensor is used for detecting the pressure borne by the SERS substrate, the blood glucose Raman signal and the pressure signal are synthesized to determine the blood glucose concentration, and the interference of blood glucose Raman signal change caused by movement of a measured part is reduced.

Description

technical field [0001] The present application relates to the medical field, in particular to a blood sugar signal collection device, a blood sugar concentration detection device and a detection system. Background technique [0002] Raman spectrometer is very effective for blood glucose concentration detection, but limited by the weak signal of Raman spectrum (usually only 10 of the incident light intensity -6 times), the Raman spectrometer is bulky and inconvenient to carry around. Based on this, the patent US9279759B2 applied the surface-enhanced Raman spectroscopy (SERS) method and used functional nanoparticle SERS substrates to greatly enhance the Raman signal. By using different metal nanostructures, 10 6 ~10 9 The signal enhancement of the Raman spectrometer provides a scalable solution for the miniaturization of the Raman spectrometer. However, it is still very difficult to apply this method to human blood glucose detection. One of the reasons is that the SERS meth...

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Problems solved by technology

However, it is still very difficult to apply this method to human blood glucose detection. One of the reasons is that the SERS method is very sensitive to distance. During the measurement process, the distance change caused by the movement of samples such as fingertips will have a serious impact on the Raman signal. Interference, resulting in inaccurate detection of blood glucose concentration

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