5 results about "Glucose signaling" patented technology

The utility model discloses a shirt capable of monitoring blood sugar, and belongs to the field of intelligent wearable equipment. The shirt comprises a shirt body, a blood glucose monitoring assembly is arranged on the shirt body, the blood glucose monitoring assembly comprises four blood glucose sensors, the four blood glucose sensors are arranged on the armpits and the back portion respectively, blood glucose signals can be accurately collected, and the blood glucose monitoring assembly is electrically connected with a microprocessor arranged on the lower hem of the back portion of the shirt and a storage battery arranged on the rear side of a collar through a flexible circuit. The flexible circuit is coated with a waterproof layer and a wear-resistant layer, the microprocessor and the storage battery are both subjected to sealing waterproof treatment, and the storage battery adopts a flexible thin film battery and is matched with a magnetic attraction contact charging mode. The waterproof flexible display screen is arranged on the cuff of the shirt, the monitoring result can be displayed in real time, the sealed waterproof NFC electronic tag is sewn at the chest portion of the inner side, and health data can be conveniently stored and read. The non-invasive, real-time and continuous blood glucose monitoring is achieved, the parts are reasonable in layout, wearing is comfortable, the protective design is durable, the functions of convenient display and data management are achieved, and powerful support is provided for health management.

The present invention relates to a method of controlling glucose in a flexible structure dual hormone artificial pancreas, the method managing optional meal and / or exercise alerts by means of coordinated control behavior, the method comprising: measuring a plasma glucose signal; calculating an incremental plasma glucose measure (y); defining an incremental plasma glucose model; defining carbohydrate uptake as a carbohydrate content estimated depending on the patient; defining an expected postprandial incremental plasma glucose according to the administered insulin bolus; defining a corrected incremental plasma glucose, a corrected insulin infusion, and a corrected carbohydrate uptake; defining a virtual control behavior, which is allocated between a regulatory behavior and an anti-regulatory behavior; and calculating the control behavior with a 2-DOF feedback controller having a pre-filter having a nominal value s).

The invention provides a continuous blood glucose monitoring signal denoising method based on a two-factor layered adaptive wavelet threshold. The method comprises the following steps: firstly, performing discrete wavelet decomposition on an original noisy blood glucose signal; then, on the basis of noise characteristics of each scale, independently designing a threshold value for each layer of decomposition by adopting a hierarchical adaptive strategy; further, a novel two-factor nonlinear threshold function is introduced to perform contraction processing on the wavelet coefficient, a smooth transition factor controls function continuity near a threshold boundary to suppress a reconstruction ringing effect, and an amplitude retention factor adjusts the attenuation degree of a large-scale wavelet coefficient to retain key physiological features such as rapid change of blood glucose; and finally, reconstructing the de-noised signal through wavelet inverse transformation. According to the method, measurement noise and baseline drift are effectively suppressed, meanwhile, the fidelity capability of dynamic characteristics such as a blood glucose trend turning point is remarkably improved, and the inherent contradiction between excessive smoothness and noise residue in a traditional wavelet threshold method is relieved.

A method for controlling glucose in a flexibly structured dual-hormone artificial pancreas that manages optional meal and / or exercise notifications using coordinated control actions, which comprises: measuring a plasma glucose signal; calculating an incremental plasma glucose measurement (y); defining a model for incremental plasma glucose; defining a carbohydrate intake as dependent on a carbohydrate content estimated by the patient; defining an expected postprandial incremental plasma glucose y*(s) depending on the insulin bolus administered; defining a corrected incremental plasma glucose y(s), a corrected insulin infusion u(s), and a corrected carbohydrate d(s) intake; defining a virtual control action µ(s), divided into regulatory actions µr and counter-regulatory actions µcr and calculating control actions using a 2-DOF feedback controller with a nominal value pre-filter Fr(s).

The application discloses a method for synchronously and efficiently metabolizing mixed sugar based on a Pichia pastoris mixed flora and application thereof. The Pichia pastoris mixed flora comprises at least one Pichia pastoris engineering strain for xylose metabolism and one Pichia pastoris engineering strain for oligosaccharide metabolism. By means of functional division of the strains, the interference of glucose signal on the xylose metabolic pathway is physically and genetically isolated, and the synchronous metabolism of xylose and cellulosic oligosaccharide is realized. The metabolic burden of each strain is reduced, the exclusive pathway of each strain can be optimized, the pathway competition and the imbalance of auxiliary factors are avoided, the overall fermentation rate and the sugar conversion rate are improved. The mixed flora system has a certain buffering capacity to environmental fluctuations and is more stable than a single strain. The strategy is particularly suitable for complex lignocellulose hydrolysate, and can effectively solve the problem of asynchronous utilization of multiple fermentable sugars in the lignocellulose hydrolysate and improve the total utilization rate of raw materials. In the process of simultaneous saccharification and fermentation of the mixed flora, the utilization rate of xylose and cellulosic oligosaccharide is improved, and the integrated biorefinery cycle is shortened.