47 results about "Glucose signaling" patented technology

In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor (824) based on the linear regression.

Production of beta-cells from stem cells from pluripotent stem cells have always been significantly lacking in at least one of the following properties: 1) functional properties related to insulin-production and glucose signaling response, 2) mature phenotype such as biochemical markers or cell structures, 3) efficiency in production of differentiated cells. Described herein is multistep differentiation protocol which substantially overcomes all of the existing limitations. Pluripotent stem cells, including induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs) can be differentiated using an embryoid body (EB) formation step, followed by B maturation via endothelial cells (EC) co-culturing and incubation with a sequential series of bone morphogenic protein (BMP)-related growth factor cocktails. The resulting cells displayed functional properties, including insulin-production and glucose signaling response, and mature phenotype of C-peptide expression.

The invention discloses a universal blood glucose prediction method based on frequency band separation and data modeling, which comprises the steps that a human body subcutaneous blood glucose measurement signal is analyzed; the latent timing sequence dynamic characteristic of the human body subcutaneous blood glucose measurement signal is extracted; a frequency band separation threshold is defined; the subcutaneous blood glucose measurement signal is divided into a high frequency band and a low frequency band; timing sequence autocorrelation of a low frequency blood glucose signal is analyzed; and an autoegression blood glucose prediction model is established. According to the universal blood glucose prediction method, re-modeling for a new object is not required after the sufficient blood glucose measurement signals are acquired, and real-time blood glucose prediction can be performed by directly calling a prediction model of other individual, so that the modeling working capacity and the complexity are simplified greatly; the modeling cost can be lowered greatly; the prediction precision is improved due to the fact that a universal model adopts a method based on frequency band separation and latent variable modeling; and the universal blood glucose prediction method is easy to implement, and indicates a new direction for research of a blood glucose prediction modeling method.

This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing. Another is to use a size exclusion filter located in line with the insulin delivery tubing in order to remove the smaller phenolic preservative molecules while allowing the larger insulin molecules to pass unimpeded. These filtration concepts can also be more broadly applied, that is, the general concept of removal of unwanted drug formulation excipients from a drug delivery system.

The invention discloses a blood glucose monitoring device based on a smart phone, and a realization method thereof. The blood glucose monitoring device is characterized in that the smart phone blood instrument comprises three main hardware systems which are a blood glucose test strip module, a blood glucose signal acquisition module, and a smart phone. According to the invention, the blood glucose monitoring device is combined with the smart phone. The blood glucose monitoring device has the advantages of small volume, convenient carrying, low cost, stable performance, and simple and reliable operation. Also, blood glucose data can be recorded for a long time, such that user and physicians can conveniently tracking blood glucose history and trends. With the monitoring device system provided by the invention, a user can also conveniently order blood glucose test strips.

The invention relates to a flexible photonic skin, which comprises a functional layer disposed, a bonding layer composed of hypoallergenic polyvinyl ethyl ether for fixing the functional layer, and anencapsulated layer adhered to the bonding layer and composed of a polyurethane semipermeable film in order from bottom to top, The functional layer consists of two electrodes on both sides for collecting human ECG signals, and a polymer-based photonic integrated chip for collecting body temperature, pulse, blood pressure and blood glucose signals between the two electrodes, and the polymer-basedphotonic integrated chip processes and outputs the collected human ECG signals, human body temperature, pulse, blood pressure and blood glucose signals. The flexible photonic skin has the advantages of anti-electromagnetic interference, small size, light weight, good temperature resistance, strong multiplexing capability, and high sensitivity, and the equivalent modulus is equivalent to the humanskin modulus. The flexible photonic skin can use a Bragg waveguide raster and a MZI electro-optic modulator to continuously monitor physiological information such as body temperature, pulse, blood pressure, blood sugar and electrocardiogram, and improves the portability and comfort of active health monitoring.

The invention discloses continuous blood glucose monitoring equipment comprising a blood glucose classification function fault detection module. According to the equipment, a blood glucose PCA monitoring chart is established to perform fault detection on a continuous blood glucose monitoring instrument so that accurate blood glucose signals can be provided. Due to the influences (such as changes of diets and the emotion of a patient) of external source input, the blood glucose fluctuation condition of the patient can change, and correspondingly the SPE value of the blood glucose signals can change obviously; besides, obvious nonlinearity exists between the blood glucose signals, and thus it is impossible to establish a unified and effective control limit for detecting whether a blood glucose meter has a fault or not. In the equipment, the blood glucose signals are divided into multiple classes, and it is ensured that signals in each class are locally linearized and the blood glucose fluctuation conditions in each class are similar, so that it is ensured that fault detection of the blood glucose meter can be better performed in each class, more accurate and credible data are provided for subsequent blood glucose prediction, control and the like, and the equipment has great significance.

The invention relates to a method for detecting ractopamine content in food. The method is characterized by comprising the following steps: preparing a capture probe; preparing a signal probe, treating a sample to be detected, and detecting by using a glucometer. Compared with the prior art, the method has the advantages that the signal is converted into a glucose signal which can be detected by the glucometer through an enzymatic effect, field detection of a nonsugar glucometer is realized, the stability is high, the detection limit is low, the detection range is wide. Moreover, the detection cost is low, the detection program is simple, the detection effect is good, particularly general staff can perform field detection, and the strict requirement that the professional staff need to operate in a lab in the prior art is avoided.

This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucoseconcentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

The invention provides a method for distinguishing wild radix astragali from cultured radix astragali. The method comprises the following steps of acquiring a nuclear magnetic resonance hydrogen spectrum of radix astragali crude medicine by a nuclear magnetism technology, respectively carrying out manual integration on sucrose, alpha-glucose and beta-glucose signals, calculating the integral area ratio of sucrose to glucose, and judging the growth pattern of the unknown radix astragali crude medicine according to the range of the ratio to accurately distinguish the wild radix astragali from the cultured radix astragali. The method can be used for identifying the quality of the radix astragali crude medicine.

The invention discloses a method for detecting SARS-Cov-2 by using a blood glucose meter. The method includes the following steps: (1) designing a nucleic acid probe 1 and a nucleic acid probe 2 according to a target nucleic acid sequence of the SARS-Cov-2, and preparing magnetic bead-nucleic acid probe 1 and invertase-nucleic acid probe 2; (2) mixing the magnetic bead-nucleic acid probe 1 and theinvertase-nucleic acid probe 2 with a sample to be tested to obtain a mixture, wherein the mixture is used to jointly capture the target nucleic acid sequence in the sample to be tested; (3) converting the signal of the target nucleic acid sequence captured in the step (2) into a glucose signal to obtain a mixed solution to be tested; and (4) detecting the converted glucose signal in the mixed solution to be tested by using the blood glucose meter to obtain the amount of the SARS-Cov-2 in the sample to be tested. The method provided by the invention detects the amount of glucose through the blood glucose meter to obtain the amount of a biomarker, can realize the purpose of simple and rapid detection, and can obtain quantitative detection results, the results can be digitally output by theblood glucose meter, and the method is short in consumed time and low in cost.

A medical monitoring unit for continuously monitoring a glucose value and a lactate value is provided. The monitoring unit comprises: a display unit, a first unit adapted to: receive a glucose / lactate / pyruvate signal based on a measured glucose / lactate / pyruvate value, transform the glucose signal into a graphically displayable glucose / lactate / pyruvate signal, and transmit the graphically displayable glucose / lactate / pyruvate signal to the display unit of the monitoring unit, and a second unit adapted to: receive a glucose / lactate / pyruvate signal based on a measured glucose / lactate / pyruvate value, transform the glucose / lactate / pyruvate signal into a graphically displayable glucose / lactate / pyruvate signal, and transmit the graphically displayable glucose / lactate / pyruvate signal to the display unit of the monitoring unit. Furthermore, a system comprising the monitoring unit, and a sensor unit for sensing glucose and / or lactate and / or pyruvate values, is provided, as well as a method for performing the steps made possible through the provided unit and method.

The invention relates to a portable blood glucose detection device transmitting data based on an earphone audio interface. The portable blood glucose detection device comprises a blood glucose signal acquisition device, wherein the blood glucose signal acquisition device comprises a block device main body and sheet blood glucose test paper; and a slot for inserting the blood glucose test paper is formed in the device main body. The portable blood glucose detection device is characterized by also comprising a smart phone, wherein an earphone jack is formed in the smart phone; the device main body is provided with an earphone plug corresponding to the earphone jack; and the earphone plug protrudes out of the surface of the device main body. According to the portable blood glucose detection device provided by the invention, an analysis detection part adopts the existing smart phone loaded with corresponding software, and the traditional display screen and input button are saved so that the blood glucose signal acquisition device is independent and can be made into a small and light structure which is convenient to carry. Since the earphone jack, namely an audio interface is formed in the smart phone, the blood glucose signal acquisition device can establish connection with the smart phone anytime conveniently through the earphone jack to realize a blood glucose detection function.

The invention discloses a glucometer system with an automatic diagnosis function. The glucometer system comprises a glucometer with a data transmission function and a central machine station, and the glucometer with the data transmission function is connected with the central machine station through a communication network. The glucometer with the data transmission function comprises a data signal collecting module, a blood glucose signal processing module, a data compression module, a communication module, a display module, a key module and a power supply management module. The central machine station comprises an automatic diagnosis module, a data receiving and sending module, a storage module and a display module. Through the mode, the glucometer system with the automatic diagnosis function is convenient to carry, can measure blood glucose at any time and can send blood glucose data to the central machine station for analysis and diagnosis through the network, and a user can know own blood glucose condition by receiving feedback information.

The invention discloses a method for detecting clenbuterol hydrochloride residues based on a blood glucose meter, which belongs to the technical field of biological detection and immunosensors. The method comprises the following steps: (1) coating a clenbuterol hydrochloride complete antigen on the surfaces of magnetic beads, and blocking to obtain an immunomagnetic bead probe; (2) adding a secondary antibody to a colloidal gold solution, mixing, adding an invertase to obtain an enzyme-labeled secondary antibody; (3) adding the immunomagnetic bead probe and anti-clenbuterol hydrochloride antibody to to-be-detected solution, performing immunological reaction and magnetic separation to obtain a magnetic bead / antigen-antibody immune complex; and then adding the enzyme-labeled secondary antibody, performing reaction and magnetic separation to obtain a magnetic bead / antigen-antibody / enzyme-labeled secondary antibody immune complex; and (4) adding a sucrose solution to the magnetic bead / antigen-antibody / enzyme-labeled secondary antibody immune complex, performing hydrolysis reaction, detecting a glucose signal value with a blood glucose meter, and obtaining the clenbuterol hydrochloride residual level in the to-be-detected solution according to a standard curve. The method disclosed by the invention has the characteristics of simplicity in operation, fastness and accuracy in detection, high sensitivity, and the like.

The invention discloses a method for detecting clenbuterol hydrochloride residues based on a blood glucose meter, which belongs to the technical field of biological detection and immunosensors. The method comprises the following steps: (1) coating a clenbuterol hydrochloride complete antigen on the surfaces of magnetic beads, and blocking to obtain an immunomagnetic bead probe; (2) adding a secondary antibody to a colloidal gold solution, mixing, adding an invertase to obtain an enzyme-labeled secondary antibody; (3) adding the immunomagnetic bead probe and anti-clenbuterol hydrochloride antibody to to-be-detected solution, performing immunological reaction and magnetic separation to obtain a magnetic bead / antigen-antibody immune complex; and then adding the enzyme-labeled secondary antibody, performing reaction and magnetic separation to obtain a magnetic bead / antigen-antibody / enzyme-labeled secondary antibody immune complex; and (4) adding a sucrose solution to the magnetic bead / antigen-antibody / enzyme-labeled secondary antibody immune complex, performing hydrolysis reaction, detecting a glucose signal value with a blood glucose meter, and obtaining the clenbuterol hydrochloride residual level in the to-be-detected solution according to a standard curve. The method disclosed by the invention has the characteristics of simplicity in operation, fastness and accuracy in detection, high sensitivity, and the like.

The invention relates to a noninvasive blood glucose detection device. The device comprises a microwave cavity, a voltage system, a temperature and moisture signal processing module, a signal demodulation processing module, a microcontroller, a display system module, a warning system module, a memory and a calibration reset module; the microcontroller module analyzes and processes temperature andmoisture blood glucose signals and demodulation signals to generate a blood glucose concentration value and compares the generated blood glucose concentration value with a normal value of the blood glucose concentration in the memory; the device can conduct continuous, noninvasive and accurate blood glucose detection on patients.

The invention relates to a blood glucose meter for realizing noninvasive rapid detection of blood glucose based on a portable differential Raman spectrum technology. Firstly, Raman spectrum acquisition is conducted on the middle part of a little finger nail of a human body by utilizing two beams of light sources with different wavelengths to obtain two groups of blood glucose Raman data with tiny frequency shift; a fluorescence background is removed through a difference algorithm, a specific blood glucose signal is captured, direct multiple iteration deconvolution algorithm reduction is conducted on a Raman characteristic signal generated after difference, and an original Raman spectrum of the human body blood glucose is obtained; and finally, after Raman peak position matching of a standard glucose solution, an exact blood glucose concentration value can be output according to the corresponding relation between the spectral line intensity and the blood glucose concentration. According to the blood glucose meter, exciting light and collecting light share the same light path, on the basis that the size is effectively reduced, the convenience and usability of blood glucose monitoring are greatly improved, and any pretreatment is not needed. The blood glucose meter is convenient to operate, high in detection speed and high in accuracy, and has great guiding significance in prevention and treatment of diabetes mellitus.

This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing. Another is to use a size exclusion filter located in line with the insulin delivery tubing in order to remove the smaller phenolic preservative molecules while allowing the larger insulin molecules to pass unimpeded. These filtration concepts can also be more broadly applied, that is, the general concept of removal of unwanted drug formulation excipients from a drug delivery system.

The invention relates to a blood glucose signal collecting device connected with a smart phone and used for blood glucose testing. The smart phone comprises a USB (Universal Serial Bus) socket; the blood glucose signal collecting device comprises a block-shaped device main body and a flaky blood glucose test strip; a slot used for inserting the blood glucose test strip is formed in the device body; the blood glucose signal collecting device is characterized in that a USB plug matched with the USB socket is also arranged on the device body; and the USB plug protrudes out the surface of the device body. The blood glucose signal collecting device can be rapidly connected with the smart phone through the USB plug, and is matched with the smart phone to realize a blood glucose testing function. The blood glucose signal collecting device is small in size and convenient to carry, utilizes an existing USB socket of the smart phone, can be stably connected with the smart phone, can be prevented from rotating relative to the smart phone and prevented from affecting the stably operation of the blood glucose signal collecting device or from falling off and being damaged, and can be used while the USB plug is plugged.

The invention discloses a universal blood glucose prediction method based on frequency band separation and data modeling, which comprises the steps that a human body subcutaneous blood glucose measurement signal is analyzed; the latent timing sequence dynamic characteristic of the human body subcutaneous blood glucose measurement signal is extracted; a frequency band separation threshold is defined; the subcutaneous blood glucose measurement signal is divided into a high frequency band and a low frequency band; timing sequence autocorrelation of a low frequency blood glucose signal is analyzed; and an autoegression blood glucose prediction model is established. According to the universal blood glucose prediction method, re-modeling for a new object is not required after the sufficient blood glucose measurement signals are acquired, and real-time blood glucose prediction can be performed by directly calling a prediction model of other individual, so that the modeling working capacity and the complexity are simplified greatly; the modeling cost can be lowered greatly; the prediction precision is improved due to the fact that a universal model adopts a method based on frequency band separation and latent variable modeling; and the universal blood glucose prediction method is easy to implement, and indicates a new direction for research of a blood glucose prediction modeling method.

A glucose annunciator comprising: i) a data eavesdropping interface configured to acquire blood glucose data transmitted by a wireless glucose monitor, the blood glucose data indicating a blood glucose level of a subject; and ii) an alert generator coupled to the data eavesdropping interface and configured to generate at least one of an audible indicium, a visible indicium, or a haptic indicium based on the blood glucose data but remote from the wireless glucose monitor. The indicium at least generally indicates the blood glucose level of the subject without requiring access to the wireless glucose monitor.

The invention provides a flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets, and belongs to the technical field of biomedical instruments. The core structure of the contact lens is made of a gamma-Fe2O3@NiO magnetic oxide nanosheet material, and the material is combined with different parts of an electrochemical signal acquisition system, an external metal coil and a Teslameter, so that detection of three biological signals, namely, an eyeball tremor signal, an intraocular pressure signal and a glucose signal, is realized at the same time; namely detection of different physiological signals is achieved only through one sensor; meanwhile, the contact lens is high in sensitivity, relatively outstanding in reliability and stability, capable of carrying out real-time detection, simple in structure, low in price and easy to produce on a large scale.

The invention relates to the technical field of food safety detection immunoassay, in particular to a portable high-sensitivity ractopamine immunoassay determination kit and application thereof. The kit comprises a ractopamine standard substance, a ractopamine magnetic nanoprobe, a ractopamine nanogold nanoprobe and an ssDNA-invertase conjugate. The kit can be used for specifically and quantitatively detecting the content of ractopamine. The kit has the advantages of simplicity, rapidness, sensitivity, specificity, stability and the like. Moreover, the detection system provided by the invention is operated in an open manner, is simple, convenient and rapid, is particularly suitable for being popularized and used by vast quality inspection institutions, and provides a very valuable detection means for food safety detection. The kit provided by the invention is combined with a portable glucometer for use, the sensitivity is greatly improved by detecting a glucose signal value corresponding to the rolling circle DNA, and a more sensitive, rapid and reliable basis can be provided for detection of ractopamine in food.

The invention discloses a watch capable of monitoring blood glucose of a human body in real time without skin puncturing. The watch comprises a watch head, watchbands and a display screen. The watchbands are hinged to the two ends of the watch head, the display screen is embedded into the watch head, and a non-invasive blood glucose detection system is installed in the watch head and comprises a blood glucose signal collecting module, a signal conditioning module, a signal collecting and transmitting module and a power module, and further comprises a Bluetooth mule, a voice prompt module and atiming module. The watch is high in monitoring efficiency, measures the blood glucose of a user in real time through a non-invasive mode, avoids the pains of the user, does not need to sample blood,and is wide in application range.

The present invention relates to a method and apparatus for correction of non-invasive blood glucose measurement, and more specifically, to a method for correcting a blood glucose signal measured from a video image of the white light reflected from the skin. The present invention provides a method and apparatus for measuring the exact amount of blood glucose in blood by extracting fundamental blood glucose signals. The method may comprise the steps of irradiating white light on the skin by using a white light source, filtering the white light reflected from the skin by a first wavelength filter and a second wavelength filter, obtaining a first signal including a blood glucose signal and a pulse signal based on a video image generated by the white light filtered by the first wavelength filter, obtaining a second signal including a pulse signal based on a video image generated by the white light filtered by the second wavelength filter, obtaining a blood glucose signal by subtracting the second signal from the first signal, and calculating the amount of blood glucose in a subcutaneous blood vessel based on the obtained blood glucose signal. According to the method and apparatus for correction of non-invasive blood glucose measurement disclosed in the present invention, fundamental blood glucose signals can be extracted in real time by a method that does not collect blood.

The invention discloses a blood glucose sensor. The blood glucose sensor comprises an upper insulating layer, a separation layer, an enzyme reaction region, an electrode and a lower insulating layer in sequence from top to bottom, wherein a siphon channel is formed in one end of the separation layer; the electrode is partially exposed into the siphon channel and at least comprises a timing electrode and a temperature sensing electrode; and the temperature sensing electrode is partially exposed into the siphon channel. The invention further discloses a glucometer taking the blood glucose sensor as a blood glucose signal input source. The accuracy of an existing blood glucose test can be greatly improved.

The invention relates to the field of medicine, and concretely relates to a blood glucose signal acquisition device, and a blood glucose concentration detection device and system. The blood glucose signal acquisition device comprises a bottom plate, an SERS substrate, a pressure sensor and a Raman spectrometer, wherein the bottom plate is provided with a through hole part; the SERS substrate is mounted on the bottom plate, and at least partial area of the SERS substrate is arranged in the through hole part; the pressure sensor is arranged on the SERS substrate or the bottom plate and is used for detecting the pressure borne by the SERS substrate; and the Raman spectrometer is arranged below the SERS substrate. Compared with the prior art, the Raman spectrometer is used for collecting the blood glucose Raman signal through the SERS substrate, the pressure sensor is used for detecting the pressure borne by the SERS substrate, the blood glucose Raman signal and the pressure signal are synthesized to determine the blood glucose concentration, and the interference of blood glucose Raman signal change caused by movement of a measured part is reduced.